Home Chemistry Heterocyclic Building Blocks Pyridines 5-Bromo-2-Chloropyridine
Substitution Reactions: The bromo and chloro substituents can undergo substitution reactions with various nucleophiles or electrophiles. For example, they can be replaced by other functional groups such as hydroxyl, amino, alkyl, or acyl groups through nucleophilic substitution or electrophilic substitution reactions.
Cross-Coupling Reactions: 5-Bromo-2-chloropyridine can participate in cross-coupling reactions, such as Suzuki-Miyaura coupling or Heck reaction, to form biaryl compounds or other organic molecules.
Nucleophilic Aromatic Substitution (SNAr): The electron-deficient pyridine ring can undergo nucleophilic aromatic substitution reactions with strong nucleophiles to replace the bromo or chloro substituents.
Metalation Reactions: The pyridine ring can be metalated using strong bases to generate reactive intermediates that can subsequently undergo various transformations such as coupling reactions or functional group interconversion.
Redox Reactions: The bromo and chloro substituents can undergo redox reactions under appropriate conditions, such as metal-mediated or radical reactions, leading to the formation of different oxidation states or functional groups.
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(5-Bromo-2-chloropyridin-4-yl)boronic acid
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5-Bromo-2-chloro-3-nitropyridin-4-amine
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5-Bromo-2-chloro-4-(difluoromethyl)pyridine
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1-(5-Bromo-2-chloropyridin-4-yl)ethanone
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5-Bromo-2-chloro-4-(trifluoromethyl)pyridine
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5-Bromo-2-chloro-4-(difluoromethoxy)pyridine
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