Chemistry Organic Building Blocks Iodides 1-Fluoro-3-Iodo-2-Methylbenzene

1-Fluoro-3-Iodo-2-Methylbenzene

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —I,—CH3,—F).

Metalation Reactions: Iodobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Alkylation: Similar to acylation, toluene can also undergo Friedel-Crafts alkylation reactions, where an alkyl group is introduced onto the benzene ring. Alkylation reactions also require a Lewis acid catalyst.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.

Further Reading:

Framework+−

(2-Iodophenyl)(Phenyl)Methanone (2-Iodophenyl)Methanol (3-Iodophenyl)Boronic Acid (3-Iodophenyl)Methanol 1,2-Benziodoxol-3-(1H)-One 1,2-Difluoro-3-Iodobenzene 1,2-Diiodobenzene 1,3-Dibromo-2-Iodobenzene 1,3-Dichloro-2-Iodobenzene 1,3-Difluoro-2-Iodobenzene 1,3-Diiodo-2-Phenoxybenzene 1,3-Diiodobenzene 1,4-Dibromo-2-Iodobenzene 1,4-Difluoro-2-Iodobenzene 1-(2-Iodophenyl)Ethan-1-One 1-(3-Iodophenyl)Ethan-1-One 1-(Benzyloxy)-4-Iodobenzene 1-(Bromomethyl)-2-Iodobenzene 1-Benzyl-4-Iodo-1H-Pyrazole 1-Bromo-2-Iodobenzene 1-Bromo-3-Fluoro-2-Iodobenzene 1-Bromo-3-Iodobenzene 1-Bromo-4-Iodobenzene 1-Chloro-2-Fluoro-3-Iodobenzene 1-Chloro-2-Iodobenzene 1-Chloro-3-Iodo-2-Methylbenzene 1-Chloro-3-Iodobenzene 1-Chloro-4-Iodobenzene 1-Ethyl-2-Iodobenzene 1-Fluoro-2-Iodo-4-Methylbenzene 1-Fluoro-2-Iodobenzene 1-Fluoro-3-Iodo-2-Methylbenzene 1-Fluoro-3-Iodobenzene 1-Fluoro-4-Iodobenzene 1-Iodo-2,3-Dimethylbenzene 1-Iodo-2,4-Dimethylbenzene 1-Iodo-2-(Trifluoromethoxy)Benzene 1-Iodo-2-(Trifluoromethyl)Benzene 1-Iodo-2-Isopropylbenzene 1-Iodo-2-Methoxybenzene 1-Iodo-2-Methylbenzene 1-Iodo-2-Nitrobenzene 1-Iodo-3-(Trifluoromethoxy)Benzene 1-Iodo-3-(Trifluoromethyl)Benzene 1-Iodo-3-Methoxybenzene 1-Iodo-3-Methylbenzene 1-Iodo-3-Nitrobenzene 1-Iodo-4-Methoxybenzene 1-Iodo-4-Phenoxybenzene 2,4-Difluoro-1-Iodobenzene 2,6-Dichloro-4-Iodopyridine 2,6-Diiodoaniline 2,6-Diiodophenol 2-Bromo-3-Iodopyridine 2-Bromo-4-Chloro-1-Iodobenzene 2-Bromo-6-Iodoaniline 2-Bromo-6-Iodopyridine 2-Chloro-3-Iodopyridin-4-Amine 2-Chloro-3-Iodopyridine 2-Chloro-4-Iodopyridine 2-Chloro-5-Iodopyridine 2-Chloro-6-Iodophenol 2-Chloro-6-Iodopyridine 2-Fluoro-1-Iodo-4-Methylbenzene 2-Fluoro-3-Iodopyridine 2-Fluoro-6-Iodoaniline 2-Hydroxy-3-Iodobenzaldehyde 2-Iodo-1,3-Dimethylbenzene 2-Iodo-1,4-Dimethylbenzene 2-Iodo-1-Methyl-4-Nitrobenzene 2-Iodo-4-Methylaniline 2-Iodo-6-Methylpyridine 2-Iodo-6-Nitroaniline 2-Iodo-9H-Fluorene 2-Iodo-N,N-Dimethylaniline 2-Iodoaniline 2-Iodobenzaldehyde 2-Iodobenzamide 2-Iodobenzene-1,3-Diol 2-Iodobenzoic Acid 2-Iodobenzonitrile 2-Iodonaphthalene 2-Iodophenol 2-Iodopyrazine 2-Iodopyridine 2-Iodopyrimidine 2-Iodothiophene 3-Chloro-2-Iodoaniline 3-Chloro-4-Iodoaniline 3-Fluoro-2-Iodoaniline 3-Iodo-1-Methyl-1H-Pyrazole 3-Iodo-1H-Pyrrolo[2,3-B]Pyridine 3-Iodo-1H-Pyrrolo[3,2-B]Pyridine 3-Iodo-2-Methylaniline 3-Iodoaniline 3-Iodobenzaldehyde 3-Iodobenzoic Acid 3-Iodobenzonitrile 3-Iodoimidazo[1,2-A]Pyridine 3-Iodophenol 3-Iodopyridazine 3-Iodopyridin-2-Amine 3-Iodopyridin-2-Ol 3-Iodopyridin-4-Amine 3-Iodopyridin-4-Ol 3-Iodopyridine 3-Iodotetrahydrofuran 4-Bromo-2-Chloro-1-Iodobenzene 4-Bromo-2-Fluoro-1-Iodobenzene 4-Bromo-2-Iodoaniline 4-Chloro-2-Iodoaniline 4-Chloro-3-Iodoaniline 4-Chloro-5-Iodopyrimidine 4-Fluoro-2-Iodoaniline 4-Fluoro-3-Iodobenzoic Acid 4-Iodo-1,1'-Biphenyl 4-Iodo-1H-Pyrazole 4-Iodo-N,N-Diphenylaniline 4-Iodopyridine 4-Iodopyrimidine 5-Bromo-2-Iodopyridine 5-Iodo-1H-Imidazole 5-Iodo-1H-Pyrazole 5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine 5-Iodopyridin-2-Amine 5-Iodopyridin-2-Ol 5-Iodopyrimidine 6-Chloro-5-Iodopyridin-2-Amine Ethyl 2-Iodobenzoate Ethyl 3-Iodobenzoate Methyl 2-Iodobenzoate Methyl 3-Iodo-4-Methylbenzoate Methyl 3-Iodobenzoate Methyl 4-Amino-3-Iodobenzoate N-(2-Iodophenyl)Acetamide Phenyl(O-Tolyl)Iodonium Tert-Butyl 3-Iodo-1H-Indole-1-Carboxylate

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3-Iodopropyl Diiodo Diiodobenzoate Fluoro-Iodo-Nitro-Benzene Fluoroiodobenzene Iodo-Benzofuran Iodo-Fluorene Iodo-Indazol-Amine Iodo-Indazole Iodo-Indazole-Carboxylate Iodo-Indole Iodo-Isoquinoline Iodo-Methyl-Pyrazole Iodo-Pyrazole-Carboxylate Iodo-Pyrazolopyridine Iodo-Pyrrolopyridine Iodo-Pyrrolopyridine-Carboxylate Iodo-Pyrrolopyrimidine Iodo-Trifluoromethyl-Pyridine Iodoacetate Iodoaniline Iodoanisole Iodobenzaldehyde Iodobenzamide Iodobenzene Iodobenzoate Iodobenzotrifluoride Iodobutane Iodobutane Iodoethane Iodoethane Iodoethoxy Iodoethoxy Iodoethyl Iodoethyl Iodohexane Iodohexane Iodoimidazo Iodomethyl Iodomethyl Iodomethyl-Imidazole Iodomethyl-Indazole Iodonicotinaldehyde Iodonicotinate Iodonicotinic Iodonicotinic Iodonitrobenzene Iodopropane Iodopropane Iodopropyl Iodopropyl Iodopyrazolo Iodopyrimidine Iodotoluene

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