Home Chemistry Heterocyclic Building Blocks Pyridines 4-Bromo-2-Chloropyridine
Substitution Reactions: The halogen atoms in the molecule (bromine and chlorine) are susceptible to nucleophilic substitution reactions. For instance, they can be substituted by various nucleophiles such as amines, alcohols, or thiols.
Metalation: The pyridine ring can undergo metalation reactions where a metal replaces a hydrogen atom on the ring. Common metals used for metalation include lithium, magnesium, and zinc.
Cross-Coupling Reactions: The halogen atoms can participate in cross-coupling reactions such as Suzuki, Stille, or Heck reactions, where they react with suitable partners to form new carbon-carbon or carbon-heteroatom bonds.
Functional Group Transformations: The functional groups present in 4-bromo-2-chloropyridine can undergo various transformations, such as oxidation, reduction, or addition reactions, to yield different derivatives.
Ring Closure Reactions: The pyridine ring can participate in ring-closure reactions to form cyclic compounds under appropriate conditions, such as cyclization reactions mediated by strong bases or electrophilic aromatic substitution reactions.
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4-Bromo-2-chloro-6-(trifluoromethyl)pyridin-3-amine
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4-Bromo-5-(bromomethyl)-2-chloropyridine
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