Home Chemistry Heterocyclic Building Blocks Pyridines 6-Methylpyridin-2-Ol
Substitution Reactions: The hydroxyl group (-OH) can undergo substitution reactions, where it is replaced by another functional group or atom. For instance, it can be converted into a halogenated derivative through reaction with a halogenating agent like thionyl chloride or phosphorus tribromide.
Oxidation Reactions: The hydroxyl group can be oxidized to form a carbonyl group (aldehyde or ketone) under appropriate conditions. Oxidizing agents such as chromic acid (H2CrO4) or potassium permanganate (KMnO4) can facilitate this reaction.
Esterification Reactions: The hydroxyl group can react with an acid to form an ester. For example, reaction with acetic acid in the presence of a dehydrating agent like sulfuric acid (H2SO4) can yield the corresponding acetate ester.
Alkylation Reactions: The pyridine ring can undergo alkylation reactions, where the methyl group is replaced by another alkyl group. This can be achieved through reaction with alkyl halides in the presence of a base.
Acylation Reactions: The pyridine ring can also undergo acylation reactions, where an acyl group (-CO-R) is introduced onto the ring. This can be accomplished through reaction with acyl halides or acid anhydrides in the presence of a Lewis acid catalyst.
Reduction Reactions: The carbonyl group, if formed via oxidation of the hydroxyl group, can be reduced back to the corresponding alcohol using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Condensation Reactions: The compound can participate in condensation reactions, where two molecules combine with the loss of a small molecule such as water or hydrogen chloride to form a larger molecule. This could occur, for example, in the formation of heterocyclic compounds by condensation with appropriate carbonyl compounds or other nucleophiles.
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5-Chloro-2-hydroxy-6-methylnicotinic acid
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5-Chloro-2-hydroxy-6-methylnicotinonitrile
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5-Bromo-2-hydroxy-6-methyl-3-nitropyridine
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2-Hydroxy-6-methylpyridine-3-carboxylic acid
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Methyl 5-bromo-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
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3-(Aminomethyl)-4-methoxy-6-methylpyridin-2-ol
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4-Amino-6-methylpyridin-2-ol hydrochloride
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