CerK (Ceramide Kinase) is an enzyme responsible for catalyzing the conversion of ceramide into ceramide-1-phosphate (C1P), a key member of the ceramide metabolic pathway. CerK is primarily located on the cell membrane and participates in a variety of biological reactions and signaling pathways, including cell growth, death, differentiation, and inflammatory responses, by regulating the intracellular levels of C1P. The activity and expression of CerK vary among different cell types and tissues, having significant implications for disease states such as cancer and inflammation. Gene-specific expression and mutations can lead to dysfunctional CerK activity, thereby affecting the physiological and pathological processes of cells.