Home Chemistry Organic Building Blocks Fluorinated Building Blocks 4-Fluoro-1-Methyl-2-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —F,—NO2,—CH3).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Nitration: Nitrobenzene can undergo nitration reactions, where a nitro group (-NO2) is introduced onto the benzene ring. This is typically achieved by treating nitrobenzene with a mixture of concentrated sulfuric acid and concentrated nitric acid.
Alkylation: Similar to acylation, toluene can also undergo Friedel-Crafts alkylation reactions, where an alkyl group is introduced onto the benzene ring. Alkylation reactions also require a Lewis acid catalyst.
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1-(5-Fluoro-2-methyl-3-nitrophenyl)ethanone
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1-Chloro-2-fluoro-5-methyl-4-nitrobenzene
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1-Bromo-2-fluoro-5-methyl-4-nitrobenzene
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Methyl 2-fluoro-5-methyl-4-nitrobenzoate
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