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Quality Control of [ 6915-18-0 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 6915-18-0 ]

CAS No. :	6915-18-0	MDL No. :	N/A
Formula :	C₄H₄O₄	Boiling Point :	-
Linear Structure Formula :	HOOCCHCHCOOH	InChI Key :	-
M.W :	116.07	Pubchem ID :	-
Synonyms :

Safety of [ 6915-18-0 ]

Signal Word:		Class:
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Hazard Statements:		Packing Group:

Application In Synthesis of [ 6915-18-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 6915-18-0 ]
Downstream synthetic route of [ 6915-18-0 ]

[ 6915-18-0 ] Synthesis Path-Upstream 1~3

1
[ 74-89-5 ]
[ 6915-18-0 ]
[ 930-88-1 ]

Reference： [1] Chemistry - A European Journal, 2014, vol. 20, # 44, p. 14256 - 14260

2
[ 106-95-6 ]
[ 6915-18-0 ]
[ 999-21-3 ]

Reference： [1] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 363 - 370

3
[ 95-57-8 ]
[ 695-99-8 ]
[ 144-62-7 ]
[ 6915-18-0 ]

Reference： [1] Research on Chemical Intermediates, 2012, vol. 38, # 8, p. 1781 - 1790

[ 6915-18-0 ] Synthesis Path-Downstream 1~19

1
[ 54925-64-3 ]
[ 6915-18-0 ]
C₁₆H₃₂O₄Si₂ [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2000,vol. 166,p. 71 - 81

2
[ 56-84-8 ]
[ 636-61-3 ]
[ 4198-33-8 ]
[ 6915-18-0 ]

Yield	Reaction Conditions	Operation in experiment
0.1% - 0.4%Spectr.; 86 - 87%; 0.1% - 0.2%Spectr.	With hydrogenchloride; sodium nitrite; In water; at -15 - 0℃; for 8h;	To a vigorously stirred mixture of mother waters and washing waters (approximately 650 ml) from the previous reaction are added 200 g (1.50 mol) of L-aspartic acid, 360 ml (428.4 g) of 37% HCl (158.51 g of HCl, 4.35 mol) and 100 ml of demineralised water; 184 g (2.66 mol) of solid sodium nitrite are then added in approximately 2 hours at a temperature of ?5 C. under nitrogen blanket. Stirring is continued at the same temperature for 2.5 hours, the temperature is raised to +0 C. in the space of approximately 1 hour, the mixture is left at this temperature for another period of 1 hour, and the temperature then lowered to ?15 C. After 1.5 hours at this temperature, the mixture is vacuum filtered on Buchner filters and left to drain under vacuum pump aspiration for approximately 0.5 hours. The solid is then washed with 80 ml of water at 0 C. and left on a vacuum filter for another 1.5 hours. [00082] The crude product is vacuum dried in an oven at 40 C. It presents approximately 15-20% sodium chloride contamination. [00083] The molar percentages of the impurities present, calculated on the basis of the NMR spectrum, are the following: [TABLE-US-00002] fumaric acid 0.1-0.2% w/w malic acid 0.1-0.4% w/w aspartic acid 0.1-0.2% w/w [00084] The yield of S-(?)-chlorosuccinic acid, calculated 100% pure, is 86-87%. [00085] The pure product, obtained by means of a further crystallisation of a sample of the crude product with water, has a melting point of 180-182 C. [00086] The overall yield of reactions A+B is 83-84%.
0.1 - 0.4%Spectr.; 80 - 81%; 0.1% - 0.2%Spectr.	With hydrogenchloride; sodium chloride; sodium nitrite; In water; at -15 - 0℃; for 7h;	To a vigorously stirred mixture of 200 g (1.50 mol) of L-aspartic acid, 40 g of sodium chloride (0.68 mol), 440 ml (523.6 g) of 37% HCl (193.74 g of HCl, 5.32 mol), 200 ml of demineralised water, 100 ml of washing waters of the solid obtained in REACTION B (see Example 2), are added 184 g (2.66 mol) of solid sodium nitrite in approximately 2 hours at a temperature of -5 C. under nitrogen blanket. Stirring is continued at the same temperature for 2.5 hours, the temperature is raised to +0 C. in the space of approximately 1 hour, the mixture is left at this temperature for another period of 1 hour and then the temperature is lowered to ?15 C. After 1.5 hours at that temperature, the mixture is vacuum filtered on Buchner filters and left to drain under vacuum pump aspiration for approximately 0.5 hours. The solid is then washed with 80 ml of water at 0 C. and left on a vacuum filter for another 1.5 hours. [00078] The crude product is vacuum dried in an oven at 40 C. It presents approximately 15-20% sodium chloride contamination. [00079] The molar percentages of the impurities present, calculated on the basis of the NMR spectrum, are the following: [TABLE-US-00001] fumaric acid 0.1-0.2% w/w malic acid 0.1-0.4% w/w aspartic acid 0.1-0.2% w/w [00080] The yield of chlorosuccinic acid, calculated 100% pure, is 80-81%.

Reference： [1]Patent: US6677476,2004,B1 .Location in patent: Page column 9
[2]Patent: US6677476,2004,B1 .Location in patent: Page column 9

3
[ 6915-18-0 ]
[ 223796-20-1 ]
[ 223796-21-2 ]

Yield	Reaction Conditions	Operation in experiment
85%	In methanol; diethyl ether;	A solution of 1-(3-pyridyl)-4-tert-butoxycarbonylhomopiperazine (0.91 g, 3.3 mmol), trifluoroacetic acid (7.5 g, 66 mmol) and dichloromethane (30 ml) was stirred for 15 h. The mixture was evaporated. Sodium hydroxide (30 ml, 4 M) was added. The product was extracted two times with dichloromethane (30 ml) and isolated as an oil. Yield 0.50 g, 85%. The corresponding salt was obtained by addition of a diethyl ether and methanol mixture (9:1) saturated with fumaric acid. Mp 172.1-172.9 C.

Reference： [1]Patent: US2004/72823,2004,A1 .Location in patent: Page/Page column 16

4
[ 50-00-0 ]
[ 6915-18-0 ]
[ 223794-26-1 ]
[ 223794-27-2 ]

Yield	Reaction Conditions	Operation in experiment
34%	In methanol; diethyl ether; ethyl acetate	1.A A solution of 1-(3-pyridyl)-piperazine (0.35 g, 2.1 mmol), formic acid (1.0 g, 21.7 mmol), formaldehyde (0.64 g, 37 %) and water (2 ml) was stirred at reflux for 15 h. The mixture was evaporated and sodium hydroxide (30 ml, 1 M) was added and the product was extracted three times with ethyl acetate (15 ml). The corre sponding salt was obtained by addition of a diethyl ether and methanol mixture (9:1) saturated with fumaric acid. Yield 0.21 g, 34 %. Mp 144.5-145.9° C.

Reference： [1]Current Patent Assignee: DANPET - US2004/72823, 2004, A1 Location in patent: Page/Page column 13

5
[ 6915-18-0 ]
[ 110-15-6 ]

Yield	Reaction Conditions	Operation in experiment
98%	With hydrogen; In ethanol; at 20℃; under 760.051 Torr; for 2.0h;	General procedure: In a typical reaction, 0.015 g of catalyst and 2 mmol of the reactant were taken in 10 mL of ethanol under hydrogen atmosphere. The reaction was monitored by thin-layer chromatography (TLC). After complete disappearance of the starting material, the catalyst was separated by simple filtration and the solvent was removed under reduced pressure to obtain the pure product.

Reference： [1]Journal of Molecular Catalysis A: Chemical,2012,vol. 365,p. 115 - 119
[2]Advanced Synthesis and Catalysis,2012,vol. 354,p. 663 - 669
[3]Patent: WO2016/32403,2016,A1 .Location in patent: Page/Page column 15; 16
[4]Canadian Journal of Chemistry,2012,vol. 90,p. 758 - 761
[5]Transition Metal Chemistry,2011,vol. 36,p. 699 - 706
[6]Catalysis Communications,2010,vol. 11,p. 928 - 931
[7]Organic Process Research and Development,2012,vol. 16,p. 1230 - 1234

6
[ 106-95-6 ]
[ 6915-18-0 ]
[ 999-21-3 ]

Reference： [1]European Journal of Organic Chemistry,2014,vol. 2014,p. 363 - 370

7
[ 82410-79-5 ]
aqueous cadmium chloride [ No CAS ]
[ 7732-18-5 ]
[ 6915-18-0 ]
[Cd₂(1,4-bis(2-methylimidazol-1-ylmethyl)benzene)₂(fumarate)Cl₂]*0.5H₂O}_n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
38%	With sodium hydroxide; In ethanol; at 110.0℃; for 72h;pH 7.0;Autoclave;	General procedure: A solution of H2fum (0.2 mmol) or H2glu (0.2 mmol) in 5 mL H2O was adjusted to pH7 with dilute NaOH. Then bix (0.2 mmol) in 5 mL EtOH and CdCl2·2.5H2O (0.2 mmol) in 5 mL H2O were added. The mixture was added to a 30 mL Teflon-lined stainless autoclave and this was sealed and heated to 110C for 3days and then cooled to room temperature to give the colorless crystals 1 in 38% yield based on Cd(II) (0.036 g) or 2 in 46% yield based on Cd(II) (0.035 g). Anal. calcd. for C36H39Cd2Cl2N8O4.50 (1) C, 45.45; H, 4.13; N, 11.78. Found: C, 45.39%; H, 4.08%; N, 11.74%. Anal. calcd. for C26H30Cd2N4O8 (2) C, 41.56; H, 4.02; N, 7.46. Found: C, 41.53%; H, 3.97%; N,7.44 %.

Reference： [1]Inorganic Chemistry Communications,2014,vol. 46,p. 24 - 28

8
[ 82410-79-5 ]
zinc(II) nitrate hexahydrate [ No CAS ]
[ 6915-18-0 ]
[Zn(fumarate)(1,4-bis(2-methylimidazol-1-ylmethyl)benzene)_0.5]·0.5H₂O}_n [ No CAS ]

Reference： [1]Crystal Growth and Design,2014,vol. 14,p. 1047 - 1056

9
[ 1206161-97-8 ]
[ 6915-18-0 ]
(x)C₄H₄O₄*C₂₁H₂₃N₅O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran; water; acetone; at 25 - 50℃; for 22h;	2.4.2. Maleic Acid10294] Compound 1 (246.4 mg, 0.58 mmol, 1 eq.) is suspended in 5% water in acetone (4.95 mE, 20 vols) at 25 C. and the sample is warmed to 50C. Maleic acid (1 M solution in THF) (1.2 mE, 1.22 mmol, 2.1 eq.) is added to the stirred suspension at 50 C. The mixture is cooled to 25 C. at 1 C/mm and stirred at 25 C. for 22 h.10295] The solid was isolated by vacuum filtration and dried under suction.10296] The XRPD analysis confirmed the formation of the formation of a stable non-hygroscopic salt, having an aqueous solubility measured at 0.4 mgmL.

Reference： [1]Patent: US2015/225398,2015,A1 .Location in patent: Paragraph 0294; 0295; 0296

10
[ 101-84-8 ]
[ 2417-10-9 ]
[ 52995-00-3 ]
[ 120-80-9 ]
[ 123-31-9 ]
[ 6915-18-0 ]
[ 3588-17-8 ]
[ 108-95-2 ]

Reference： [1]RSC Advances,2016,vol. 6,p. 20357 - 20365

11
[ 1134-35-6 ]
manganese(II) chloride tetrahydrate [ No CAS ]
[ 6915-18-0 ]
[Mn₂(fumarato)₂(5,5'-dimethyl-2,2'-bipyridine)₂(H₂O)] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42%	Stage #1: 2-butenedioic acid With sodium hydroxide In methanol; water at 20℃; Stage #2: 4,4'-dimethyl-2,2'-bipyridines; manganese(II) chloride tetrahydrate In methanol; water at 20℃; for 144h;	A solution of fumaric acid (0.0348 g; 0.3 mmol) in methanol (5 ml) was added to an aqueous solution (5 ml) of sodium hydroxide (0.0240 g; 0.6 mmol), while stirring. Then, a solution of MnCl2*4H2O (0.0593 g; 0.3 mmol) in deionized water (5 ml) was added, under constant stirring. Finally, a solution of 4,4'-dimethyl-2,2'-bipyridine (0.0552 g; 0.3 mmol) in methanol (5 ml) was added. A translucent yellow solution was obtained. After six days, the yellow crystals so obtained were filtered out, washed with a 50:50 deionized water-methanol mixture and air dried. Yield: 42 % based on metal precursor. Anal. calc.for C32H34Mn2N4O11 (FW = 724.48): C, 53.05; H, 4.17; N, 7.73 %. Found: C, 52.86; H, 4.29; N, 7.68 %. IR(cm-1): 3630 (s), 3500 (s, br), 3080 (m), 3060(s), 2960 (m), 2920 (m), 1960 (m), 1940 (m), 1880 (w), 1820 (w), 1600(vs), 1550 (vs), 1480 (s), 1390 (s), 1300 (m), 1240 (m), 1210 (m), 1130 (w), 1010 (s), 980 (m), 918 (s), 833 (s), 802(s), 706 (m), 690 (vs, sh), 660 (s), 586 (s), 548 (m), 513(m), 424 (w).

Reference： [1]Téllez-López, Antonio; Sánchez-Mendieta, Víctor; Jaramillo-García, Jonathan; Rosales-Vázquez, Luis D.; García-Orozco, Iván; Morales-Luckie, Raúl A.; Escudero, Roberto; Morales-Leal, Francisco [Transition Metal Chemistry, 2016, vol. 41, # 8, p. 879 - 887]

12
[ 58-33-3 ]
[ 6915-18-0 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: phenergan; 2-butenedioic acid In acetonitrile for 1.5h; Milling; Stage #2: In acetonitrile at 4.84℃; for 48h;	2.1.2. Preparation of PTZ-Cl-fumaric Promethazine hydrochloride (150 mg) was mixed with fumaric acid (27.2 mg)in a 2:1 molar ratio. The powder was mechanically activated ina ball mill for 90 min at 27 Hz after the addition of a few drops of acetonitrile. In order to obtain single crystals, the powderobtained in the mill was recrystallized from acetonitrile (4 ml).The solution obtained was kept at 278 K for 48 h and afterwardsat room temperature, allowing for slow evaporation ofthe solvent and for crystals suitable for single-crystal X-raystructure analysis to be obtained.
	In acetonitrile at 4.84℃; for 48h;

Reference： [1]Borodi, Gheorghe; Turza, Alexandru; Onija, Oana; Bende, Attila [Acta Crystallographica Section C: Structural Chemistry, 2019, vol. 75, # 2, p. 107 - 119]
[2]Borodi, Gheorghe; Turza, Alexandru; Onija, Oana; Bende, Attila [Acta Crystallographica Section C: Structural Chemistry, 2019, vol. 75, p. 107 - 119]

13
[ 26787-78-0 ]
[ 3973-08-8 ]
[ 740742-98-7 ]
[ 64-18-6 ]
[ 79-14-1 ]
[ 110-94-1 ]
[ 124-04-9 ]
[ 80-69-3 ]
[ 473-81-4 ]
[ 471-47-6 ]
[ 110-15-6 ]
[ 1378848-02-2 ]
[ 15573-67-8 ]
C₉H₁₀N₂O₄ [ No CAS ]
C₉H₁₂N₂O₅S [ No CAS ]
C₈H₁₀N₂O₆S [ No CAS ]
C₉H₁₄N₂O₇S [ No CAS ]
C₉H₁₂N₂O₆S [ No CAS ]
C₈H₁₀N₂O₄S [ No CAS ]
C₁₀H₁₂N₂O₇S [ No CAS ]
C₁₅H₂₁N₃O₄S [ No CAS ]
C₁₅H₁₈N₂O₄S [ No CAS ]
C₁₄H₂₁N₃O₃S [ No CAS ]
C₈H₁₂N₂O₄S [ No CAS ]
C₈H₁₀N₂O₅S [ No CAS ]
C₆H₁₀O₇S [ No CAS ]
C₆H₇NO₄S [ No CAS ]
C₆H₁₁NO₃S [ No CAS ]
C₆H₉NO₃S [ No CAS ]
[ 144-62-7 ]
[ 64-19-7 ]
[ 802294-64-0 ]
[ 127-17-3 ]
[ 87-69-4 ]
[ 551-16-6 ]
[ 65-85-0 ]
[ 298-12-4 ]
2-hydroxy-3-(4-hydroxyphenyl)pyrazine [ No CAS ]
[ 6915-18-0 ]
[ 107-92-6 ]
[ 57457-65-5 ]
[ 99-96-7 ]

Reference： [1]Catalysis Today,2019

14
[ 34580-20-6 ]
[ 1235342-53-6 ]
[ 6915-18-0 ]
C₂₅H₂₄N₂OS*C₄H₄O₄ [ No CAS ]

Reference： [1]Patent: CN107021954,2020,B .Location in patent: Paragraph 0113

15
[ 31480-93-0 ]
[ 6915-18-0 ]
C₂₅H₂₂O₈ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
28.7 g	With dicyclohexyl-carbodiimide; In dichloromethane; at 20℃; for 4h;	Add 35.6g (0.2mol) compound 1 in the reaction flask11.6g (0.1mol) compound 2, 500ml dichloromethane stirred,Add 51.7g (0.25mol) DCC at room temperature, then stir at room temperature for 4 hours,Check that the raw materials disappeared; add water and stir to separate the layers. The aqueous layer was extracted twice with dichloromethane and the dichloromethane layers were combined, washed with water, dried over anhydrous sodium sulfate, spin-dried to dry the solvent, dissolved in toluene, and then chromatographed on a silica gel column. It was recrystallized twice with toluene and ethanol to obtain the target compound, 28.7 g of white solid, HPLC: 99.2%. The resulting NMR spectrum of the compound represented by formula I is shown in FIG. 1.

Reference： [1]Patent: CN112812011,2021,A .Location in patent: Paragraph 0152-0158

16
[ 881681-00-1 ]
[ 6915-18-0 ]
[ 2648971-67-7 ]

Yield	Reaction Conditions	Operation in experiment
72.75%	In methanol; toluene at 25 - 35℃;	1-3 Preparation of compound 6 Between 25 and 35°C, add 750 g of the methanol solution of compound 6 fumaric acid to the toluene solution of compound 4 obtained in the previous step. During the dropwise addition, white solids are precipitated in the system. , the filter cake was dried at 50°C to obtain a white solid; Add 1kg of purified water and 1kg of methanol to the white solid obtained in the previous step, heat up to 65-70°C, stir to dissolve, keep stirring at 0-10°C for crystallization for 1-2h, and filter. The filter cake was rinsed once with methanol-water mixture, and the filter cake was dried at 45° C. to obtain 203.15 g of white solid compound 7, vonolaxan fumarate, with a purity of 100%, mono-hetero

Reference： [1]Current Patent Assignee: HANGZHI PHARMACEUTICAL - CN114539219, 2022, A Location in patent: Paragraph 0039; 0052-0055; 0056; 0065-0068; 0077-0079

17
[ 111-71-7 ]
[ 6915-18-0 ]
[ 4144-54-1 ]

Yield	Reaction Conditions	Operation in experiment
95%	With tetrabutylammonium decatungstate In lithium hydroxide monohydrate; acetonitrile at 30℃; Inert atmosphere; Irradiation;

Reference： [1]Jorea, Alexandra; Ravelli, Davide; Romarowski, Rodrigo M.; Marconi, Stefania; Auricchio, Ferdinando; Fagnoni, Maurizio [ChemSusChem, 2022]

18
[ 2647442-33-7 ]
[ 6915-18-0 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
71%	In ethanol at 20℃; for 0.5h;	5 Example 5: Preparation of (2R,3R,4R,5R)-2-(4-amino-5-deuterated pyrrolo[2,1-f][1,2,4]triazin-7-yl)- 2-cyano-5-(isobutyryloxymethyl)tetrahydrofuran-3,4-diylbis(2-methylpropionate)maleate Compound Z (2.85 g, 5.67 mmol) was dissolved in absolute ethanol (20 mL), maleic acid (0.66 g, 5.67 mmol) was added, heated to reflux, and the reaction solution was cooled to room temperature after 30 minutes, and n-heptane ( 40mL), a large amount of cotton wool-like solid was precipitated, the temperature was raised to 45°C, stirred for 1.5 hours, then cooled to 0°C, continued to stir for 30 minutes, filtered, and the filtrate was dried to obtain the title compound in the form of a white solid (2.5g, yield 71 %, HPLC purity 98.9%).

Reference： [1]Current Patent Assignee: SUZHOU VIGONVITA LIFE SCIENCES; CHINESE ACADEMY OF SCIENCES; Shanghai Institute of Materia Medica (in: CAS); SUZHOU WANWANG SHANWANGSHUI BIOLOGICAL MEDICINE LTD - CN114391016, 2022, A Location in patent: Paragraph 0120-0124

19
[ 737789-87-6 ]
[ 6915-18-0 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
10 g	In chloroform at 20℃;	13 Example 13 preparation of relugo limaleate The crude relugoli (12.5g) prepared in Example 2 was sequentially added with chloroform (0.12L) and maleic acid (3.48g, 0.03mol, 1.5eq.) at room temperature, after feeding, stirring for 3 hours, solids precipitated, continued stirring for 12 hours, filtered, and the filter cake was washed withCHCl 3(50mL). The wet product is vacuum dried to obtain relugo limaleate (white solid; 10.0g HPLC purity: 98.99%)

Reference： [1]Current Patent Assignee: CHINA NATIONAL PHARMACEUTICAL GROUP CORPORATION - CN115626933, 2023, A Location in patent: Paragraph 0103-0106

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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6915-18-0 ] {[proInfo.proName]}

Quality Control of [ 6915-18-0 ]

Related Doc. of [ 6915-18-0 ]

Product Details of [ 6915-18-0 ]

Safety of [ 6915-18-0 ]

Application In Synthesis of [ 6915-18-0 ]

[ 6915-18-0 ] Synthesis Path-Upstream 1~3

[ 6915-18-0 ] Synthesis Path-Downstream 1~19

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry