The Fer/FerT family belongs to the non-receptor tyrosine kinases, including Fer and its closely related counterpart, FerT. These kinases mediate a variety of intracellular signaling pathways through their structure comprising FCH and SH2 domains, primarily located in the cytoplasm. Fer/FerT play crucial roles in regulating cytoskeletal reorganization, cell adhesion, migration, and cancer progression. They are involved in multiple signaling pathways, such as interactions with the PI3K/Akt and MAPK pathways, influencing cell survival and proliferation. Specific gene expressions and mutations are closely associated with tumorigenesis and development, with Fer overexpression observed in various cancers, suggesting its potential as a therapeutic target.