The PDGFR family includes PDGFRα and PDGFRβ, which are receptor tyrosine kinases located on the cell surface. Each receptor is composed of a single polypeptide chain with five immunoglobulin-like domains. They are primarily situated on the cell membrane and, upon binding with platelet-derived growth factor (PDGF), activate signaling pathways involved in cell proliferation, migration, and survival, such as the PI3K/Akt and MAPK pathways. PDGFRs are expressed in various cell types and tissues, including blood vessels, the immune system, and the central nervous system. Specific expression and mutations of PDGFR genes are associated with various diseases, including cancer, cardiovascular diseases, and fibrotic diseases. Mutations or overexpression of PDGFR can lead to aberrant activation of signaling pathways, promoting tumor growth and angiogenesis.