Home Chemistry Heterocyclic Building Blocks Pyrrolidines 1-(Phenylsulfonyl)Pyrrolidine
Nucleophilic Substitution (SN) Reactions: The sulfonyl group is electron-withdrawing, which makes the carbon atom it's attached to partially electrophilic. This can make it susceptible to nucleophilic attack. For instance, a strong nucleophile could potentially replace the sulfonyl group.
Reduction: The phenylsulfonyl group may be reduced to a phenyl group under certain conditions using appropriate reducing agents.
Acidic Hydrolysis: Under strong acidic conditions, the compound could undergo hydrolysis, potentially leading to cleavage of the sulfonyl group.
Basic Hydrolysis: Under strong basic conditions, the compound could undergo hydrolysis, potentially leading to cleavage of the sulfonyl group.
Grignard Reaction: The compound may react with a Grignard reagent, potentially leading to the formation of a new carbon-carbon bond.
Metalation and Cross-Coupling: The pyrrolidine ring can potentially serve as a directing group for metalation, which could be followed by various cross-coupling reactions.
Oxidation: Depending on the conditions, the compound could be oxidized, potentially leading to the formation of sulfoxides or sulfones.
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(4-(Pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(S)-1-(Phenylsulfonyl)pyrrolidin-3-amine hydrochloride
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(3-Methyl-4-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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1-(3-Bromo-4-methylphenylsulfonyl)pyrrolidine
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1-((5-Bromo-2-methoxyphenyl)sulfonyl)pyrrolidine
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(3-(Pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(4-Methoxy-3-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(2-(Pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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(2-Methyl-5-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid
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