Home Chemistry Organic Building Blocks Iodides 2-Fluoro-1-Iodo-4-Methylbenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —I,—F,—CH3).
Electrophilic Aromatic Substitution (EAS): Iodobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The presence of the iodine atom makes the ring more reactive toward electrophiles due to its electron-donating inductive effect. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Nitration: Toluene can undergo nitration, where a nitro group (-NO2) is introduced onto the benzene ring. This reaction usually requires the presence of concentrated nitric acid and sulfuric acid as a catalyst.
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