NMUR (neuromedin U receptor) is a member of the G protein-coupled receptor family, consisting of two subtypes, NMUR1 and NMUR2, each with seven transmembrane domains. They are primarily expressed in the central nervous system and peripheral tissues, such as the brain, gastrointestinal tract, and pancreas. NMURs participate in regulating physiological processes such as pain perception, appetite, digestion, and insulin secretion by recognizing neuromedin U. They activate various signaling pathways, including IP3, DAG, and cAMP. The specific expression and regulation of NMURs are crucial for pain management, energy balance, and metabolic regulation. Mutations or abnormal expression of NMURs are associated with the development of pain, obesity, and metabolic disorders.