Home Chemistry Heterocyclic Building Blocks Piperidines Piperidin-3-Amine
Nucleophilic substitution reactions: The amine group can act as a nucleophile in reactions with electrophiles, such as alkyl halides or acyl halides, leading to substitution products. This can include N-alkylation or N-acylation reactions.
Reductive amination: Piperidin-3-amine can undergo reductive amination with carbonyl compounds (aldehydes or ketones) in the presence of reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride, leading to the formation of secondary amines.
Acylation reactions: The amine group can react with acyl chlorides or anhydrides to form amides.
Ring-opening reactions: The ring nitrogen of piperidine can undergo ring-opening reactions under certain conditions, leading to the formation of open-chain compounds.
Cyclization reactions: Piperidin-3-amine can participate in intramolecular cyclization reactions under appropriate conditions, forming heterocyclic compounds.
Oxidation reactions: The amine group can be oxidized to form corresponding oximes, nitroso compounds, or N-oxides.
Mannich reaction: Piperidin-3-amine can participate in Mannich-type reactions, where it reacts with formaldehyde and a suitable carbonyl compound to yield β-amino carbonyl compounds.
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tert-Butyl (S)-3-aminopiperidine-1-carboxylate hydrochloride
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tert-Butyl 3-aminopiperidine-1-carboxylate
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(3S,5R)-tert-Butyl 3-amino-5-methylpiperidine-1-carboxylate
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tert-Butyl 3-amino-4,4-difluoropiperidine-1-carboxylate
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tert-Butyl 3-amino-4-fluoropiperidine-1-carboxylate
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(3R,4S)-rel-tert-Butyl 3-amino-4-fluoropiperidine-1-carboxylate
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