Home Chemistry Organic Building Blocks Bromides 2-Bromo-4-Chloro-1-Fluorobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—Cl).
Grignard Reaction: Bromobenzene can react with a Grignard reagent (organomagnesium compound) to form a new carbon-carbon bond, leading to the introduction of various functional groups.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Reduction: Chlorobenzene can be reduced to form cyclohexane under certain conditions, often using strong reducing agents like sodium in the presence of 【alcohol|https://www.ambeed.com/alcohols.html】.
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1-Bromo-5-chloro-2-fluoro-4-methylbenzene
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Methyl 4-bromo-2-chloro-5-fluorobenzoate
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tert-butyl 4-bromo-2-chloro-5-fluorobenzoate
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3-Bromo-5-Chloro-2-fluoroaniline hydrochloride
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