Home Chemistry Heterocyclic building blocks Pyridines 2-iodopyridine
Substitution Reactions: The iodine atom in 2-iodopyridine can undergo substitution reactions where it is replaced by another functional group. For example, nucleophilic substitution reactions with nucleophiles such as amines or thiols can lead to the formation of N- or S-substituted pyridines, respectively.
Metalation Reactions: 2-Iodopyridine can react with certain metal reagents to undergo metalation reactions. For instance, treatment with organolithium or Grignard reagents can lead to the formation of organometallic derivatives of pyridine.
Cross-Coupling Reactions: 2-Iodopyridine can participate in cross-coupling reactions, such as Suzuki-Miyaura coupling or Heck coupling, where it can be coupled with other organic substrates under the catalysis of palladium or other transition metal complexes.
Reductive Elimination Reactions: Under suitable conditions, 2-iodopyridine can undergo reductive elimination reactions, releasing iodine and forming a new carbon-carbon or carbon-heteroatom bond.
Oxidation Reactions: 2-Iodopyridine can undergo oxidation reactions, where the iodine atom is converted to other functional groups. For example, treatment with oxidizing agents such as peroxides or halogenating agents can lead to the formation of pyridine N-oxide or pyridinium salts.
Halogenation Reactions: The iodine atom in 2-iodopyridine can be replaced by other halogens through halogenation reactions, such as treatment with chlorine or bromine.
Reduction Reactions: 2-Iodopyridine can undergo reduction reactions where the iodine atom is replaced with a hydrogen atom or reduced to a lower oxidation state. This can be achieved using reducing agents such as metal hydrides or hydrogen gas in the presence of catalysts.
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tert-Butyl (2-iodopyridin-4-yl)carbamate
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