Home Chemistry Heterocyclic building blocks Pyrimidines 4,6-diphenylpyrimidine
Aromatic Substitution: The phenyl groups in 4,6-diphenylpyrimidine are susceptible to electrophilic aromatic substitution reactions. They can react with electrophiles like acyl chlorides, nitration reagents, or halogenating agents.
Reduction: 4,6-diphenylpyrimidine can undergo reduction reactions. For instance, it can be reduced using strong reducing agents like lithium aluminum hydride (LiAlH4) to produce 4,6-diphenylpyrimidin-2-amine.
Alkylation or Acylation: The nitrogen atoms in the pyrimidine ring can be alkylated or acylated under suitable conditions. For example, you can use alkyl halides or acyl chlorides along with a base.
Condensation Reactions: It can participate in condensation reactions with compounds containing active hydrogen atoms, leading to the formation of new compounds.
Oxidation: Depending on the reaction conditions, 4,6-diphenylpyrimidine may be oxidized by strong oxidizing agents to form various products.
Nucleophilic Substitution: If appropriate nucleophiles are available, nucleophilic substitution reactions can occur at positions within the pyrimidine ring.
Metalation: 4,6-diphenylpyrimidine can react with strong bases or certain organometallic reagents to form metal complexes or derivatives.
Cyclization: It can undergo intramolecular cyclization reactions if the appropriate functional groups are present in the molecule.
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4,4'-(Pyrimidine-4,6-diyl)dibenzoic acid
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4,6-Bis(3,5-dichlorophenyl)-2-methylpyrimidine
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5,5'-(5-Aminopyrimidine-4,6-diyl)diisophthalic acid
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