Home Chemistry Heterocyclic Building Blocks Indazoles 7-Bromo-1H-Indazole
Substitution Reactions: The bromine atom can undergo substitution reactions with various nucleophiles, such as amines or thiols, leading to the formation of substituted indazole derivatives.
Nucleophilic Addition: The double bond in the indazole ring can undergo nucleophilic addition reactions with nucleophiles such as organometallic reagents or cyanide ions.
Electrophilic Aromatic Substitution (EAS): The electron-rich aromatic ring can undergo EAS reactions with electrophiles, such as acyl chlorides or nitro compounds, leading to the formation of substituted products.
Reduction: The bromine atom or the nitro group (if present) can be reduced to the corresponding bromide or amines, respectively, using reducing agents such as hydrogen gas over a metal catalyst or stannous chloride.
Oxidation: If there are reducing groups present, oxidation reactions can occur to convert them to their oxidized forms.
Metalation: The hydrogen atom at the C-2 position can be replaced by a metal, such as lithium or magnesium, through metal-halogen exchange reactions.
Functional Group Interconversion: Various functional groups present on the molecule can undergo interconversion reactions, such as conversion of an amine to an amide or an alcohol to an alkyl halide.
Cyclization Reactions: The molecule can participate in cyclization reactions under certain conditions, leading to the formation of cyclic compounds with different ring sizes.
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2-(7-Bromo-1H-indazol-3-yl)acetic acid
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Ethyl 7-bromo-1H-indazole-3-carboxylate
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7-Bromo-3-methyl-1H-indazole-5-carboxylic acid
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Methyl 7-bromo-1H-indazole-5-carboxylate
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