Neutral endopeptidase (NEP), also known as CD10 or endopeptidase 24.11, is a zinc-dependent metalloproteinase responsible for the degradation of various bioactive peptides. NEP is expressed on the cell membrane of many cell types, particularly abundant in the kidneys, lungs, and immune cells. It participates in biological processes such as blood pressure regulation, pain response, and immune response by regulating the levels of peptide hormones like angiotensin and enkephalins. The expression of the NEP gene is tissue-specific, and mutations or changes in expression may be associated with various diseases, including cardiovascular diseases, cancer, and metabolic disorders.