Home Chemistry Heterocyclic Building Blocks Pyrrolidines 2-(Pyrrolidin-1-Yl)Pyridine
Acylation: The pyrrolidine nitrogen can be acylated using acyl chlorides or anhydrides to introduce various acyl groups. For example, you can form amides by reacting it with acyl chlorides.
Alkylation: The pyrrolidine nitrogen can be alkylated using alkyl halides or sulfonates to introduce alkyl groups.
Reductive Amination: It can undergo reductive amination reactions with carbonyl compounds in the presence of reducing agents like sodium cyanoborohydride to form secondary amines.
Nucleophilic Substitution: The pyridine ring can undergo nucleophilic substitution reactions, such as SN1 or SN2 reactions, depending on the conditions and the nature of the substrate.
Heterocycle Formation: It can participate in various heterocycle-forming reactions, such as ring-closing reactions to form fused or spirocyclic heterocycles.
Metal-Catalyzed Reactions: Metal-catalyzed cross-coupling reactions like Suzuki-Miyaura, Heck, or Stille reactions can be employed to functionalize the aromatic ring.
Substitution Reactions: The pyrrolidine moiety can undergo various substitution reactions depending on the electrophilic nature of the reagent.
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(6-(Pyrrolidin-1-yl)pyridin-3-yl)boronic acid
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(2-(Pyrrolidin-1-yl)pyridin-3-yl)boronic acid
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1-(5-(Aminomethyl)pyridin-2-yl)pyrrolidin-3-ol
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(6-(Pyrrolidin-1-yl)pyridin-2-yl)methanol
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N-((6-(2-Methylpyrrolidin-1-yl)pyridin-3-yl)methyl)propan-2-amine
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2-Fluoro-3-iodo-6-(pyrrolidin-1-yl)pyridine
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(2-(Pyrrolidin-1-yl)pyridin-3-yl)methanamine hydrochloride
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(S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol
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