Home Chemistry Heterocyclic Building Blocks Pyrimidines 4,6-Dichloro-2-(Methylthio)Pyrimidine
Nucleophilic Substitution: The chlorine atoms on the pyrimidine ring make it susceptible to nucleophilic substitution reactions. The nucleophilic substitution can occur at the chlorine atoms, and the methylthio group can also act as a nucleophile in certain conditions.
Alkylation: The pyrimidine ring can undergo alkylation reactions with alkyl halides or similar electrophiles, leading to the introduction of alkyl groups onto the ring.
Nucleophilic Aromatic Substitution: The pyrimidine ring is aromatic, and under certain conditions, it can undergo nucleophilic aromatic substitution reactions. The nucleophile may attack the ring, displacing one of the substituents.
Reduction: The sulfur atom in the methylthio group is reducible. Under appropriate conditions, it may undergo reduction reactions, leading to the formation of a thiol group.
Substitution of Methylthio Group: The methylthio group can be substituted or replaced by various nucleophiles or electrophiles, depending on the reaction conditions.
Cross-Coupling Reactions: The compound may participate in cross-coupling reactions, such as Suzuki-Miyaura or Stille coupling, if suitable coupling partners are present.
Halogenation: The chlorine atoms on the pyrimidine ring may undergo further halogenation reactions under certain conditions.
Oxidation: Depending on the reaction conditions, oxidation of the sulfur in the methylthio group to a sulfoxide or sulfone may occur.
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5-Bromo-4,6-dichloro-2-(methylthio)pyrimidine
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Methyl 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylate
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Ethyl 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylate
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4,6-Dichloro-2-(methylthio)pyrimidin-5-amine
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4,6-Dichloro-2-(methylthio)-5-formylpyrimidine
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4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
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4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
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4,6-Dichloro-2-(methylthio)-5-nitropyrimidine
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