Home Chemistry Organic Building Blocks Sulfamides 2-Fluorobenzenesulfonamide
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —SO2NH2,—F).
Amination: Benzenesulfonamide can be converted to primary 【amines|https://www.ambeed.com/amines.html】 by treating it with reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). This reaction replaces the sulfonamide group with an amino group (-NH2).
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
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2-Fluoro-5-(trifluoromethyl)benzene sulfonamide
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4-(Bromomethyl)-2-fluorobenzenesulphonamide
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