Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-4-(Trifluoromethyl)Pyridine
Nucleophilic substitution: The chlorine atom can be substituted by a nucleophile, leading to the formation of a new compound with a different functional group at the 2-position of the pyridine ring.
Electrophilic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile replaces one of the hydrogen atoms on the ring.
Metalation: The pyridine ring can be metalated at the 2-position or at the 4-position, depending on the reaction conditions, leading to the formation of metal-complexed pyridine derivatives.
Cross-coupling reactions: The trifluoromethyl group can participate in various cross-coupling reactions, such as Suzuki, Heck, or Sonogashira reactions, allowing the introduction of different substituents at the 4-position of the pyridine ring.
Oxidation and reduction reactions: The compound can undergo oxidation or reduction reactions, leading to the formation of compounds with different oxidation states or functional groups.
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2-Chloro-4-(trifluoromethyl)nicotinic acid
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2-(6-Chloro-4-(trifluoromethyl)pyridin-2-yl)acetonitrile
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2-Chloro-4,6-bis(trifluoromethyl)pyridine
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2-Chloro-5-fluoro-4-trifluoromethylpyridine
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6-Chloro-4-(trifluoromethyl)nicotinonitrile
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6-Chloro-4-(trifluoromethyl)nicotinic acid
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Methyl 6-chloro-4-(trifluoromethyl)nicotinate
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6-Chloro-4-(trifluoromethyl)picolinonitrile
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