Home Chemistry Organic building blocks Bromides 1-bromo-2-(difluoromethyl)benzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—CHF2).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Cross-Coupling Reactions: (Difluoromethyl)benzene can be used in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions, to form new carbon-carbon bonds with organometallic reagents.
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1-Bromo-2-(difluoromethyl)-4-fluorobenzene
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2-Bromo-1-(difluoromethyl)-4-fluorobenzene
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2-Bromo-4-chloro-1-(difluoromethyl)benzene
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