Home Chemistry Heterocyclic Building Blocks Piperidines 1-Benzylpiperidin-4-One
Reductive Amination: 1-Benzylpiperidin-4-one can undergo reductive amination reactions to form secondary or tertiary amines. This reaction typically involves the use of a reducing agent like sodium borohydride (NaBH4) or a reductive metal catalyst.
Reduction: The ketone group in 1-benzylpiperidin-4-one can be reduced to the corresponding alcohol using reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Nucleophilic Addition: The ketone group of the compound can undergo nucleophilic addition reactions with various nucleophiles, such as Grignard reagents, to form alcohol or other functionalized derivatives.
Alkylation: The piperidone ring can undergo alkylation reactions to introduce alkyl groups to the molecule. Alkylating agents like alkyl halides can be used for this purpose.
Oxidation: 1-Benzylpiperidin-4-one can undergo oxidation reactions to convert the ketone group to a carboxylic acid or other oxidized derivatives. Oxidizing agents like potassium permanganate (KMnO4) or chromium trioxide (CrO3) can be employed.
Ring-Opening Reactions: The piperidone ring can undergo ring-opening reactions to form open-chain compounds under specific conditions and with appropriate reagents.
Cyclization: Depending on the reaction conditions and reagents, 1-benzylpiperidin-4-one can undergo cyclization reactions to form cyclic compounds.
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Methyl 1-Benzyl-4-oxo-3-piperidinecarboxylate HCl
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Ethyl 1-Benzyl-4-oxo-3-piperidinecarboxylate HCl
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1-Benzyl-3,3-difluoropiperidin-4-one hydrate
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Ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate
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