ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin Motifs) is a group of metalloproteinases with Thrombospondin (TSP) repeats, responsible for degrading the extracellular matrix (ECM) and processing various biomolecules. There are 19 members in the ADAMTS family in humans, typically comprising a propeptide region, a metalloproteinase domain, a Disintegrin domain, and at least one Thrombospondin repeat. ADAMTS are primarily secreted extracellularly and participate in various biological processes such as tissue remodeling, coagulation, and inflammatory responses. Expression of family members is tissue-specific, and mutations in some members are associated with genetic diseases such as Marfan syndrome and Weill-Marchesani syndrome.