Home Chemistry Heterocyclic Building Blocks Indazoles 5-Chloro-1H-Indazole
Substitution Reactions: The chlorine atom can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution, leading to the formation of various substituted indazoles.
Reduction: The nitro group can be reduced to the corresponding amine using reducing agents such as hydrogen gas over a metal catalyst or iron powder in acidic conditions.
Oxidation: The indazole ring can be oxidized under appropriate conditions, leading to the formation of various oxidation products.
Halogenation: The indazole ring can undergo halogenation reactions, introducing halogen atoms at different positions on the ring.
Ring-closure Reactions: It can participate in ring-closure reactions with appropriate reagents, leading to the formation of fused or spirocyclic compounds.
Acylation: The nitrogen atom in the indazole ring can undergo acylation reactions to form N-acyl derivatives.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form larger fused ring systems or heterocyclic compounds.
Substitution on the Indole Ring: Functionalization reactions can occur on the indole ring, leading to the formation of various substituted indazoles.
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