The Salt-Inducible Kinase (SIK) family is part of the AMP-activated protein kinase (AMPK) superfamily, including three main members: SIK1, SIK2, and SIK3. They consist of a kinase domain, a regulatory region, and a phosphorylation site, primarily located in the cytoplasm and nucleus. The SIK family is involved in regulating energy metabolism, cell proliferation, and differentiation by influencing the cAMP signaling pathway and downstream factors such as CREB and HDACs, thereby regulating gene expression and cellular functions. The expression of the SIK family is tissue-specific, and mutations or dysregulation are associated with various diseases, including metabolic disorders, cancer, and neurodegenerative diseases.