Home Chemistry Heterocyclic Building Blocks Pyrimidines 2-(Methylsulfonyl)Pyrimidine
Nucleophilic Substitution: The sulfonyl group is electron-withdrawing, making the carbon adjacent to the sulfur atom electrophilic. This carbon can undergo nucleophilic substitution reactions with nucleophiles such as amines, thiols, or other nucleophilic species.
Base-Catalyzed Hydrolysis: The sulfonyl group may be susceptible to hydrolysis under basic conditions, leading to the formation of a carboxylic acid and a sulfonic acids.
Nucleophilic Aromatic Substitution: The pyrimidine ring in the compound may undergo nucleophilic aromatic substitution reactions, especially if there are activated positions on the ring.
Reduction: The sulfonyl group can potentially be reduced to a thiol group or further to an alkane under appropriate reaction conditions.
N-Oxide Formation: Under certain oxidative conditions, the nitrogen atoms in the pyrimidine ring may be oxidized to form N-oxides.
Alkylation or Acylation Reactions: The nitrogen atoms in the pyrimidine ring can act as nucleophiles in reactions with alkyl or acyl halides, leading to the introduction of alkyl or acyl groups.
Metalation Reactions: The hydrogen atoms on the pyrimidine ring may be replaced by metal atoms under suitable reaction conditions.
Cyclization Reactions: Depending on the reaction conditions and the presence of suitable functional groups, cyclization reactions may occur, leading to the formation of fused or spirocyclic compounds.
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tert-Butyl ((2-(methylsulfonyl)pyrimidin-4-yl)methyl)carbamate
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6-(2-(Methylsulfonyl)pyrimidin-5-yl)-N-(prop-2-yn-1-yl)hex-5-ynamide
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6-(2-(Methylsulfonyl)pyrimidin-5-yl)hex-5-ynoic acid
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2-Methanesulfonylpyrimidine-5-carboxylic acid
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4-Chloro-5-methyl-2-(methylsulfonyl)pyrimidine
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5-Bromo-2-(methylsulfonyl)pyrimidine-4-carboxylic acid
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5-Bromo-2-(methylsulfonyl)pyrimidin-4-amine
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Methyl 6-chloro-2-(methylsulfonyl)pyrimidine-4-carboxylate
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6-Chloro-N-methyl-2-(methylsulfonyl)pyrimidin-4-amine
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