Home Chemistry Heterocyclic Building Blocks Piperidines 1-(Piperidin-1-Yl)Ethan-1-One
Nucleophilic Addition: The carbonyl group can undergo nucleophilic addition reactions with nucleophiles, such as Grignard reagents or organolithium compounds, leading to the formation of alcohols.
Acylation: The nitrogen atom in the piperidine ring can undergo acylation reactions with acyl chlorides or acid anhydrides to form N-acyl derivatives.
Reduction: The carbonyl group can be reduced to the corresponding alcohols using reducing agents such as sodium borohydride or lithium aluminum hydride.
Oxidation: The alcohol group can be oxidized to the corresponding aldehyde or carboxylic acid under appropriate conditions.
Nucleophilic Substitution: The carbonyl carbon can undergo nucleophilic substitution reactions with various nucleophiles, leading to the formation of different functional groups.
Ring-opening Reactions: The piperidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Protonation: The carbonyl oxygen or the nitrogen atom in the piperidine ring can be protonated under acidic conditions.
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1-(3-(Hydroxymethyl)piperidin-1-yl)ethanone
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tert-Butyl (1-acetylpiperidin-4-yl)carbamate
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1-(4-Aminopiperidin-1-yl)ethanone hydrochloride
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1-(4-(Methylamino)piperidin-1-yl)ethanone hydrochloride
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1-(4-(Hydroxymethyl)piperidin-1-yl)ethanone
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