Home Chemistry Heterocyclic Building Blocks Piperidines 1-Benzylpiperidin-3-One
Reduction: 1-Benzylpiperidin-3-one can be reduced to form 1-benzylpiperidine using reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Nucleophilic addition: The carbonyl group in the piperidinone can undergo nucleophilic addition reactions with strong nucleophiles, such as Grignard reagents or organolithium compounds, to form various derivatives.
Acylation: 1-Benzylpiperidin-3-one can undergo acylation reactions with acyl chlorides or anhydrides to introduce acyl groups onto the nitrogen atom of the piperidine ring.
Mannich reaction: It can participate in Mannich reactions, where it reacts with formaldehyde and a primary or secondary amine to form β-amino ketones.
Reductive amination: 1-Benzylpiperidin-3-one can be involved in reductive amination reactions, where it reacts with primary or secondary amines and reducing agents to form substituted amines.
Cyclization: Depending on the reaction conditions and reagents used, 1-benzylpiperidin-3-one can undergo cyclization reactions to form various cyclic compounds.
Oxidation: The ketone group in 1-benzylpiperidin-3-one can be oxidized to a carboxylic acid or other oxidized products using appropriate oxidizing agents.
Hydrogenation: It can be subjected to hydrogenation reactions to convert the ketone group into a secondary alcohol.
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Ethyl 1-Benzyl-3-oxo-4-piperidinecarboxylate HCl
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1-Benzyl-3-piperidone Hydrochloride Hydrate
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Ethyl 1-benzyl-3-oxo-piperidine-4-carboxylate
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1-Benzyl-4-methylpiperidin-3-one hydrochloride
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