Chemistry Organic building blocks Chlorides 2-amino-3-chlorobenzoic acid

2-amino-3-chlorobenzoic acid

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—NH2,—COOH).

Sandmeyer Reaction: Chlorobenzene can be converted to other aryl halides through the Sandmeyer reaction, involving replacement of the chlorine atom with other halogens.
Oxidation: Aniline can be oxidized to form quinone and other oxidation products using strong oxidizing agents.
Friedel-Crafts Acylation: Benzoic acid can undergo Friedel-Crafts acylation reactions with aromatic compounds in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl3). This reaction results in the introduction of an acyl group (RCO-) onto the aromatic ring.

Further Reading:

Framework+−

(2,3-dichlorophenyl)boronic acid (2,6-dichlorophenyl)boronic acid (2-chloroethoxy)benzene (2-chlorophenyl)(phenyl)methanone (2-chlorophenyl)hydrazine (2-chlorophenyl)methanamine (2-chlorophenyl)methanol (2-chloropyridin-4-yl)boronic acid (3,4-dichlorophenyl)boronic acid (3-chloro-4-fluorophenyl)boronic acid (3-chlorophenyl)(phenyl)methanone (3-chlorophenyl)boronic acid (3-chlorophenyl)hydrazine (3-chlorophenyl)methanamine (3-chlorophenyl)methanol (3-chloropyridin-2-yl)methanamine (4-chlorophenyl)(phenyl)methanone (5-chloropyridin-2-yl)methanamine (chloromethanetriyl)tribenzene (chloromethylene)dibenzene 1,2,3,4-tetrachlorobenzene 1,2,4-trichlorobenzene 1,2-dibromo-3-chlorobenzene 1,2-dichloro-3-fluorobenzene 1,2-dichloro-3-methoxybenzene 1,2-dichloro-3-methylbenzene 1,2-dichloro-4-fluorobenzene 1,2-dichloro-4-methoxybenzene 1,2-dichloro-4-nitrobenzene 1,3-dibromo-2-chlorobenzene 1,3-dichloro-2-fluorobenzene 1,3-dichloro-2-iodobenzene 1,3-dichloro-2-methoxybenzene 1,3-dichloro-2-nitrobenzene 1,3-dichloroisoquinoline 1,4-dichloro-2-fluorobenzene 1,4-dichloro-2-methoxybenzene 1-(2-chlorophenyl)ethan-1-one 1-(2-chlorophenyl)piperazine 1-(3-chlorophenyl)-1h-pyrazole 1-(3-chlorophenyl)-n-methylmethanamine 1-(3-chlorophenyl)ethan-1-one 1-(3-chlorophenyl)pyrrolidine 1-(benzyloxy)-2-chlorobenzene 1-(benzyloxy)-3-chlorobenzene 1-(bromomethyl)-2-chlorobenzene 1-(bromomethyl)-3-chlorobenzene 1-(chloromethyl)-2-methylbenzene 1-benzyl-2-chlorobenzene 1-benzyl-3-chlorobenzene 1-benzyl-4-chlorobenzene 1-bromo-2,3-dichlorobenzene 1-bromo-2-chloro-3-methylbenzene 1-bromo-3-chloro-2-fluorobenzene 1-bromo-3-chloro-2-methylbenzene 1-bromo-4-chloro-2-fluorobenzene 1-chloro-2,3-difluorobenzene 1-chloro-2,4-difluorobenzene 1-chloro-2,4-dimethoxybenzene 1-chloro-2-(chloromethyl)benzene 1-chloro-2-(trifluoromethoxy)benzene 1-chloro-2-(trifluoromethyl)benzene 1-chloro-2-cyclopropylbenzene 1-chloro-2-ethoxybenzene 1-chloro-2-fluoro-3-iodobenzene 1-chloro-2-fluoro-4-nitrobenzene 1-chloro-2-iodobenzene 1-chloro-2-isocyanatobenzene 1-chloro-2-isothiocyanatobenzene 1-chloro-2-methyl-3-nitrobenzene 1-chloro-2-nitrobenzene 1-chloro-2-phenoxybenzene 1-chloro-2-propoxybenzene 1-chloro-3,5-dimethylbenzene 1-chloro-3-(chloromethyl)benzene 1-chloro-3-(trifluoromethoxy)benzene 1-chloro-3-(trifluoromethyl)benzene 1-chloro-3-fluoro-2-methylbenzene 1-chloro-3-fluoro-2-nitrobenzene 1-chloro-3-iodo-2-methylbenzene 1-chloro-3-iodobenzene 1-chloro-3-methoxybenzene 1-chloro-3-nitrobenzene 1-chloro-3-phenoxybenzene 1-chloro-4-(trifluoromethoxy)benzene 1-chloro-4-iodobenzene 1-chloro-4-methoxybenzene 1-chloro-4-phenoxybenzene 1-chloroanthracene-9,10-dione 1-chloroisoquinoline 1-chloronaphthalene 2,3,5-trichloropyridine 2,3,6-trichloropyridine 2,3-dichloroaniline 2,3-dichlorobenzaldehyde 2,3-dichlorophenol 2,3-dichloropyridine 2,4,5-trichloropyrimidine 2,4,6-trichloropyridine 2,4,6-trichloropyrimidine 2,4-dibromo-1-chlorobenzene 2,4-dichloro-1-fluorobenzene 2,4-dichloro-1-methoxybenzene 2,4-dichloro-1-nitrobenzene 2,4-dichloro-6-methylpyridine 2,4-dichloro-6-methylpyrimidine 2,4-dichlorobenzaldehyde 2,4-dichlorobenzonitrile 2,4-dichloropyridine 2,4-dichloroquinazoline 2,4-dichlorothiazole 2,5-dichlorophenol 2,5-dichloropyrazine 2,5-dichloropyridine 2,6-dichloro-3-fluoropyridine 2,6-dichloro-3-methylpyridine 2,6-dichloro-3-nitropyridine 2,6-dichloro-4-methylpyridine 2,6-dichloroaniline 2,6-dichlorobenzoic acid 2,6-dichlorobenzonitrile 2,6-dichloronicotinonitrile 2,6-dichlorophenol 2,6-dichloropyrazine 2,6-dichloropyridin-3-amine 2,6-dichloropyridine 2-(2-chlorophenyl)acetic acid 2-(2-chlorophenyl)acetonitrile 2-(2-chlorophenyl)ethan-1-ol 2-(2-chlorophenyl)pyridine 2-(2-chlorophenyl)pyrrolidine 2-(3-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(3-chlorophenyl)acetonitrile 2-(4-chlorophenoxy)acetic acid 2-(chloromethyl)-1h-benzo[d]imidazole 2-(chloromethyl)-3-methylpyridine 2-(chloromethyl)furan 2-(chloromethyl)pyridine 2-(chloromethyl)pyridine 1-oxide 2-(chloromethyl)pyrimidine 2-(chloromethyl)thiazole 2-amino-3-chlorobenzoic acid 2-amino-3-chlorobenzonitrile 2-amino-6-chlorophenol 2-bromo-1,3-dichlorobenzene 2-bromo-1,4-dichlorobenzene 2-bromo-1-chloro-4-methylbenzene 2-bromo-4-chloro-1-iodobenzene 2-bromo-4-chloro-1-methoxybenzene 2-bromo-4-chloro-1-methylbenzene 2-bromo-4-chloroaniline 2-bromo-4-chlorophenol 2-bromo-6-chloroaniline 2-bromo-6-chlorophenol 2-chloro-1,1'-biphenyl 2-chloro-1,3,5-triazine 2-chloro-1,3-difluorobenzene 2-chloro-1,3-dimethoxybenzene 2-chloro-1,3-dinitrobenzene 2-chloro-1,4-difluorobenzene 2-chloro-1,4-dimethoxybenzene 2-chloro-1-fluoro-4-nitrobenzene 2-chloro-1-methyl-3-nitrobenzene 2-chloro-1-phenylethan-1-one 2-chloro-1h-benzo[d]imidazole 2-chloro-3,6-dimethylpyridine 2-chloro-3-(trifluoromethyl)aniline 2-chloro-3-(trifluoromethyl)pyridine 2-chloro-3-fluoropyridin-4-amine 2-chloro-3-hydroxybenzaldehyde 2-chloro-3-methoxypyridine 2-chloro-3-methylaniline 2-chloro-3-methylbenzoic acid 2-chloro-3-methylbenzonitrile 2-chloro-3-methylpyrazine 2-chloro-3-methylpyridine 2-chloro-3-nitropyridine 2-chloro-4,6-dimethylpyridine 2-chloro-4-(trifluoromethyl)pyridine 2-chloro-4-ethoxypyridine 2-chloro-4-fluoro-1-nitrobenzene 2-chloro-4-fluoroaniline 2-chloro-4-fluoropyridine 2-chloro-4-methoxypyridine 2-chloro-4-methyl-1-nitrobenzene 2-chloro-4-methylaniline 2-chloro-4-methylbenzoic acid 2-chloro-4-methylpyridine 2-chloro-4-methylpyrimidine 2-chloro-4-methylthiazole 2-chloro-4-phenylpyrimidine 2-chloro-5-(trifluoromethyl)pyridine 2-chloro-5-fluoropyridin-4-amine 2-chloro-5-fluoropyridine 2-chloro-5-methoxyaniline 2-chloro-5-methylpyridine 2-chloro-5-methylpyrimidine 2-chloro-5-methylthiazole 2-chloro-5-nitropyridine 2-chloro-6-(trifluoromethyl)aniline 2-chloro-6-(trifluoromethyl)pyridine 2-chloro-6-fluoroaniline 2-chloro-6-fluorophenol 2-chloro-6-fluoropyridine 2-chloro-6-iodophenol 2-chloro-6-methoxyaniline 2-chloro-6-methoxyphenol 2-chloro-6-methoxypyridine 2-chloro-6-methyl-3-nitropyridine 2-chloro-6-methylaniline 2-chloro-6-methylnicotinonitrile 2-chloro-6-methylphenol 2-chloro-6-methylpyrazine 2-chloro-6-methylpyridine 2-chloro-6-nitroaniline 2-chloro-7h-purine 2-chloro-7h-pyrrolo[2,3-d]pyrimidine 2-chloro-9h-purine 2-chloro-n-phenylacetamide 2-chloro-n-phenylaniline 2-chloroaniline 2-chlorobenzamide 2-chlorobenzene-1,3-diamine 2-chlorobenzene-1,3-diol 2-chlorobenzene-1,4-diamine 2-chlorobenzenesulfonyl chloride 2-chlorobenzenethiol 2-chlorobenzo[d]oxazole 2-chlorobenzo[d]thiazole 2-chlorobenzoic acid 2-chlorobenzonitrile 2-chlorobenzoyl chloride 2-chlorocyclohexa-2,5-diene-1,4-dione 2-chlorofuran 2-chloroisonicotinaldehyde 2-chloroisonicotinic acid 2-chloroisonicotinonitrile 2-chloronaphthalene 2-chloronicotinic acid 2-chloronicotinonitrile 2-chlorooxazole 2-chlorophenol 2-chloropyrazine 2-chloropyridin-3-amine 2-chloropyridin-3-ol 2-chloropyridin-4-amine 2-chloropyridine 1-oxide 2-chloroquinoxaline 2-chlorothiazole 2-chlorothiophene 3,4-dichloroaniline 3,5-dichloropyridine 3,6-dichloropyridazine 3-(3-chlorophenyl)propanoic acid 3-(chloromethyl)pyridine 3-chloro-1,1'-biphenyl 3-chloro-1-methyl-1h-pyrazole 3-chloro-1-phenylpropan-1-one 3-chloro-1h-indazole 3-chloro-2-fluoroaniline 3-chloro-2-fluorobenzaldehyde 3-chloro-2-fluorobenzoic acid 3-chloro-2-fluorobenzonitrile 3-chloro-2-fluoropyridine 3-chloro-2-hydroxybenzaldehyde 3-chloro-2-methoxypyridine 3-chloro-2-methylaniline 3-chloro-2-methylpyridine 3-chloro-2-nitroaniline 3-chloro-4-(trifluoromethyl)aniline 3-chloro-4-fluoroaniline 3-chloro-4-fluorobenzoic acid 3-chloro-4-hydroxybenzaldehyde 3-chloro-4-methylaniline 3-chloro-4-methylpyridazine 3-chloro-4-nitroaniline 3-chloro-5-fluoropyridine 3-chloro-5-methylpyridine 3-chloro-5-nitropyridine 3-chloro-9h-carbazole 3-chlorobenzaldehyde 3-chlorobenzene-1,2-diamine 3-chlorobenzene-1,2-diol 3-chlorobenzenesulfonyl chloride 3-chlorobenzo[b]thiophene 3-chlorobenzoic acid 3-chlorobenzonitrile 3-chloroimidazo[1,2-a]pyridine 3-chloroisoquinoline 3-chlorophenol 3-chloropicolinic acid 3-chloropicolinonitrile 3-chloropyridazine 3-chloropyridin-2-amine 3-chloropyridin-2-ol 3-chlorothiophene 4,5-dichloropyrimidine 4,6-dichloro-2-methylpyrimidine 4,6-dichloropyridin-2-amine 4,6-dichloropyridin-3-amine 4,6-dichloropyrimidine 4-chloro-1,5-naphthyridine 4-chloro-1-phenylbutan-1-one 4-chloro-1h-indazole 4-chloro-1h-indole 4-chloro-1h-pyrazole 4-chloro-1h-pyrazolo[3,4-b]pyridine 4-chloro-1h-pyrazolo[3,4-d]pyrimidine 4-chloro-1h-pyrazolo[4,3-c]pyridine 4-chloro-1h-pyrrolo[3,2-c]pyridine 4-chloro-2,6-dimethylpyridine 4-chloro-2-methoxypyridine 4-chloro-2-phenylpyrimidine 4-chloro-3-fluoroaniline 4-chloro-3-methylaniline 4-chloro-3-methylpyridine 4-chloro-5-methylpyrimidine 4-chloro-n-phenylaniline 4-chlorobenzene-1,3-diol 4-chlorobenzenesulfonic acid 4-chlorobenzenesulfonyl chloride 4-chlorobenzo[d]thiazole 4-chloroindoline-2,3-dione 4-chloroisoquinoline 4-chloronicotinic acid 4-chloropyridazine 4-chloropyridin-2-amine 4-chloropyridine 4-chloroquinazoline 5,6-dichloro-1h-benzo[d]imidazole 5,6-dichloropyridin-2-amine 5-bromo-4-chloropyrimidine 5-chloro-1,2,3,4-tetrahydroisoquinoline 5-chloro-1h-imidazole 5-chloro-1h-indazole 5-chloro-1h-indole 5-chloro-1h-indole-2-carboxylic acid 5-chloro-1h-pyrazole 5-chloro-1h-pyrazolo[4,3-b]pyridine 5-chloro-1h-pyrrolo[2,3-b]pyridine 5-chloro-1h-pyrrolo[3,2-b]pyridine 5-chloro-2,3-dihydrobenzofuran 5-chloro-2-fluoropyridine 5-chloro-2-methoxypyridine 5-chloro-2-methylpyridine 5-chlorobenzo[b]thiophene 5-chlorobenzo[d]oxazole 5-chlorobenzo[d]thiazole 5-chloroimidazo[1,2-a]pyridine 5-chloroindolin-2-one 5-chloroisoquinoline 5-chloropicolinic acid 5-chloropicolinonitrile 5-chloropyrazolo[1,5-a]pyrimidine 5-chloropyridin-2-amine 5-chloropyridin-2-ol 5-chloropyridin-3-amine 5-chloropyrimidine 5-chloroquinazoline 6-chloro-1,2,3,4-tetrahydroisoquinoline 6-chloro-1,2,3,4-tetrahydroquinoline 6-chloro-1h-benzo[d]imidazole 6-chloro-1h-indazole 6-chloro-1h-indole 6-chloro-1h-pyrazolo[4,3-c]pyridine 6-chloro-1h-pyrrolo[2,3-b]pyridine 6-chloro-1h-pyrrolo[3,2-c]pyridine 6-chloro-2,3-dihydrobenzofuran 6-chloro-3,4-dihydro-2h-benzo[b][1,4]oxazine 6-chloro-3-nitropyridin-2-amine 6-chloro-5-(trifluoromethyl)pyridin-2-amine 6-chlorobenzo[d]oxazole 6-chlorobenzo[d]thiazole 6-chlorochroman-4-one 6-chlorochromane 6-chloroindoline 6-chloroindoline-2,3-dione 6-chloronicotinaldehyde 6-chloronicotinic acid 6-chloropicolinic acid 6-chloropicolinonitrile 6-chloropyridazin-3(2h)-one 6-chloropyridin-2-amine 6-chloropyridin-2-ol 6-chloropyridin-3-amine 6-chloropyridine-3-sulfonyl chloride 6-chloroquinoxaline 7-chloro-1,2,3,4-tetrahydroisoquinoline 7-chloro-1h-indazole 7-chloro-1h-indole 7-chloro-1h-pyrrolo[2,3-c]pyridine 7-chloro-2,3-dihydrobenzofuran 7-chloro-3,4-dihydronaphthalen-1(2h)-one 7-chlorobenzo[d]thiazole 7-chlorochromane 7-chloroisoquinoline 7-chloropyrazolo[1,5-a]pyrimidine 8-chlorochromane 8-chloroimidazo[1,2-a]pyridine 8-chloroisoquinoline 8-chloroquinazoline Ethyl 4,6-dichloronicotinate Ethyl 5-chloro-1h-indole-2-carboxylate Ethyl 6-chloropicolinate Ethyl 7-chloro-1h-indole-2-carboxylate Methyl 2,6-dichlorobenzoate Methyl 2-chloro-4-fluorobenzoate Methyl 2-chloro-6-fluorobenzoate Methyl 2-chlorobenzoate Methyl 2-chloroisonicotinate Methyl 2-chloronicotinate Methyl 3-chlorobenzoate Methyl 3-chloropicolinate Methyl 6-chloropicolinate N-(2-chlorophenyl)acetamide N-(3-chlorophenyl)benzenesulfonamide N-(3-chlorophenyl)quinazolin-4-amine N-(4-chlorophenyl)acetamide Phenyl carbonochloridate Pyridine-2-sulfonyl chloride Pyridine-3-sulfonyl chloride Tert-butyl (2-chloropyridin-4-yl)carbamate

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2,2,2-trichloro-ethanone 2-chloro-n-acetamide 2-chloro-n-methyl-acetamide 2-chloro-n-methylacetamide 2-chloroacetyl 2-chloroethyl 3-chloro-1-propanone 3-chloro-propanamide 3-chloropropyl 4-chloro-butan-1-one 4-chlorobutyl Benzothiazole-chloride Benzoxazole-chloride Bromo-chloro-benzene Carbonochloridate Chlorindole-carboxylic acid Chlorindole-carboxylic-acid Chloro-benzimidazole Chloro-benzoxazine Chloro-carbazole Chloro-fluoro-benzene Chloro-imidazopyridine Chloro-indazole Chloro-indazole-carboxylate Chloro-inden-amine Chloro-inden-one Chloro-indene Chloro-indole-carboxylate Chloro-iodo-trifluoromethyl-pyridine Chloro-methyl indole Chloro-methyl-indazole Chloro-methyl-pyrazole Chloro-naphthyridin-one Chloro-naphthyridine Chloro-nitrobenzene Chloro-one Chloro-phenyl-boronic-acid Chloro-propylamine-hydrochloride Chloro-purine Chloro-pyrazolamide Chloro-pyrazole Chloro-pyrazole-carboxylate Chloro-pyrazolopyridine Chloro-pyrrolopyridine Chloro-pyrrolopyrimidine Chloro-thiadiazole Chloro-trifluoromethyl-pyridin-amine Chloro-trifluoromethyl-pyridine Chloroacetamide Chloroacetyl Chloroaniline Chlorobenzaldehyde Chlorobenzamide Chlorobenzene Chlorobenzenesulfonamide Chlorobenzofuran Chlorobenzothiazole Chlorobenzotrifluoride Chlorobenzyl Chlorobutyl Chlorobutyl Chlorocarbonyl Chlorochroman Chloroethoxy Chloroethoxy Chloroethyl Chloroethylamino Chloroimidazo Chloroindole Chloroisobenzofuran Chloromethyl Chloromethylbutyl Chlorooxazole Chlorophenyl Chlorophthalazin Chloropicolinaldehyde Chloropicolinamide Chloropropane Chloropropane Chloropropoxy Chloropropoxy Chloropropyl Chloropyrazine Chloropyridazine Chloropyridine Chloropyrimidine Chloroquinazoline Chloroquinoline Chloroquinoxaline Chlorotoluene Dichloride Dichloro Dichloroaniline Dichloroanthracene Dichlorobenzaldehyde Dichlorobenzamide Dichlorobenzenesulfonamide Dichloroisonicotinaldehyde Dichloromethyl Dichloromethyl Dichloronicotinaldehyde Dichloronicotinate Dichloronicotinic Dichloronicotinic Dichloronicotinic acid Dichloropalladium Dichloropalladium Dichloropyridazine Dichloropyrimidine Dichloroquinoline Nicotinoyl-chloride Tetrachloro Tetrachloro Tetrahydroisoquinoline-chloride Tetrahydroquinoline-chloride Trichloride Trichloro Trichloro Trichloroacetimidate Trichloroaniline Trichlorobenzaldehyde Trichloroethyl Trichloroethyl Trichloromethyl Trichloromethyl

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Acridines Aliphatic heterocycles Aromatic heterocycles Azetidines Benzimidazoles Benzisoxazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Carbazoles Cinnolines Dioxolanes Dioxoles Furans Guanidines Imidazoles Imidazolidines Imidazolines Indazoles Indoles Indolines Isoquinolines Isothiazoles Isoxazoles Morpholines Naphthyridines Other aliphatic heterocycles Other aromatic heterocycles Oxadiazoles Oxazoles Oxazolidines Phthalazines Piperazines Piperidines Purines Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Tetrazoles Thiadiazoles Thiazoles Thiophenols Triazines Triazoles

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acyl chlorides alcohols aldehydes aliphatic chain hydrocarbons aliphatic cyclic hydrocarbons alkenyls alkyls alkynyls amides amidines Amines anhydrides Aryls benzyl bromides benzyl chlorides Bromides carboxylic acid salts carboxylic acids Chiral building blocks difluoromethyls esters ethers fluorinated building blocks hydrazides hydrazines hydrazones hydroxylamines iodides ketones nitriles nitroes oximes phenols phosphoruses sulfamides sulfides sulfonates sulfones sulfonic acids sulfonyl hydrazides sulfoxides thioesters Thiophenes thioureas trifluoromethyls ureas

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RCl

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    2-Amino-3-chlorobenzoic acid

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