Home Chemistry Heterocyclic Building Blocks Pyridines 3-Bromo-5-Chloropyridine
Nucleophilic Substitution: The bromine atom in 3-bromo-5-chloropyridine can be substituted by various nucleophiles. For example, it can undergo substitution reactions with nucleophiles such as amines, alcohols, or thiols to yield substituted products.
Metalation: The compound can undergo metalation reactions where the bromine or chlorine atom can be replaced by a metal ion. This reaction can be used for further functionalization or as a step in synthesis.
Cross-coupling Reactions: 3-Bromo-5-chloropyridine can participate in cross-coupling reactions such as Suzuki coupling, Stille coupling, or Heck coupling. In these reactions, it can react with appropriate coupling partners under catalytic conditions to form biaryl compounds.
Reduction: The compound can undergo reduction reactions to convert the halogen substituents to hydrogen atoms or other functional groups. For instance, it can be reduced to the corresponding pyridine derivative using reducing agents like lithium aluminum hydride or hydrogen gas over a catalyst.
Electrophilic Aromatic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions at positions where electron density is increased due to the presence of halogen substituents. For instance, it can react with electrophiles such as nitration reagents or Friedel-Crafts reagents to introduce new substituents onto the pyridine ring.
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1-(3-Bromo-5-chloropyridin-2-yl)ethanol
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N-(3-Bromo-5-chloropyridin-2-yl)formamide
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2-(5-Bromo-3-chloropyridin-2-yl)acetonitrile
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1-(5-Bromo-3-chloropyridin-2-yl)ethanone
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