Home Chemistry Organic Building Blocks Bromides 3-Bromo-4-Fluorophenol
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—OH).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Hydroxylation: Phenol can be hydroxylated using various oxidizing agents to introduce additional hydroxyl groups onto the ring.
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1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethanone
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4-Bromo-5-fluoro-2-hydroxybenzaldehyde
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Methyl 4-bromo-5-fluoro-2-hydroxybenzoate
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