Home Chemistry Heterocyclic Building Blocks Pyridines Isonicotinamide
Acetylation: Isonicotinamide can undergo acetylation reactions, where acetyl groups (-COCH3) are introduced into its structure. This reaction is commonly employed in organic synthesis to modify the properties of isonicotinamide derivatives.
Oxidation: Being a derivative of niacin, isonicotinamide can undergo oxidation reactions under certain conditions. This oxidation can lead to the formation of various products depending on the reaction conditions.
Amidation: Isonicotinamide contains an amide functional group (-CONH2), which can participate in amidation reactions. Amidation involves the conversion of the amide group into other functional groups, such as esters or acid chlorides.
Substitution Reactions: The nitrogen atom in the pyridine ring of isonicotinamide can undergo nucleophilic substitution reactions, where a substituent replaces the hydrogen atom bonded to the nitrogen atom.
Complexation Reactions: Isonicotinamide can form complexes with metal ions due to the presence of the nitrogen atom in its structure. These complexes may have various applications in coordination chemistry and catalysis.
Reduction: Isonicotinamide can be reduced to its corresponding amine, nicotinamide, under certain reaction conditions. This reduction may involve the addition of hydrogen atoms or hydride ions to the molecule.
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2-Chloro-N-(piperidin-4-yl)isonicotinamide hydrochloride
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