Chemistry Organic building blocks Chlorides 1-chloro-3-fluoro-2-nitrobenzene

1-chloro-3-fluoro-2-nitrobenzene

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—NO2,—F).

Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Sulfonation: Nitrobenzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. Sulfonation is carried out using concentrated sulfuric acid, which leads to the substitution of one of the hydrogen atoms on the ring.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.

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(2,3-dichlorophenyl)boronic acid (2,6-dichlorophenyl)boronic acid (2-chloroethoxy)benzene (2-chlorophenyl)(phenyl)methanone (2-chlorophenyl)hydrazine (2-chlorophenyl)methanamine (2-chlorophenyl)methanol (2-chloropyridin-4-yl)boronic acid (3,4-dichlorophenyl)boronic acid (3-chloro-4-fluorophenyl)boronic acid (3-chlorophenyl)(phenyl)methanone (3-chlorophenyl)boronic acid (3-chlorophenyl)hydrazine (3-chlorophenyl)methanamine (3-chlorophenyl)methanol (3-chloropyridin-2-yl)methanamine (4-chlorophenyl)(phenyl)methanone (5-chloropyridin-2-yl)methanamine (chloromethanetriyl)tribenzene (chloromethylene)dibenzene 1,2,3,4-tetrachlorobenzene 1,2,4-trichlorobenzene 1,2-dibromo-3-chlorobenzene 1,2-dichloro-3-fluorobenzene 1,2-dichloro-3-methoxybenzene 1,2-dichloro-3-methylbenzene 1,2-dichloro-4-fluorobenzene 1,2-dichloro-4-methoxybenzene 1,2-dichloro-4-nitrobenzene 1,3-dibromo-2-chlorobenzene 1,3-dichloro-2-fluorobenzene 1,3-dichloro-2-iodobenzene 1,3-dichloro-2-methoxybenzene 1,3-dichloro-2-nitrobenzene 1,3-dichloroisoquinoline 1,4-dichloro-2-fluorobenzene 1,4-dichloro-2-methoxybenzene 1-(2-chlorophenyl)ethan-1-one 1-(2-chlorophenyl)piperazine 1-(3-chlorophenyl)-1h-pyrazole 1-(3-chlorophenyl)-n-methylmethanamine 1-(3-chlorophenyl)ethan-1-one 1-(3-chlorophenyl)pyrrolidine 1-(benzyloxy)-2-chlorobenzene 1-(benzyloxy)-3-chlorobenzene 1-(bromomethyl)-2-chlorobenzene 1-(bromomethyl)-3-chlorobenzene 1-(chloromethyl)-2-methylbenzene 1-benzyl-2-chlorobenzene 1-benzyl-3-chlorobenzene 1-benzyl-4-chlorobenzene 1-bromo-2,3-dichlorobenzene 1-bromo-2-chloro-3-methylbenzene 1-bromo-3-chloro-2-fluorobenzene 1-bromo-3-chloro-2-methylbenzene 1-bromo-4-chloro-2-fluorobenzene 1-chloro-2,3-difluorobenzene 1-chloro-2,4-difluorobenzene 1-chloro-2,4-dimethoxybenzene 1-chloro-2-(chloromethyl)benzene 1-chloro-2-(trifluoromethoxy)benzene 1-chloro-2-(trifluoromethyl)benzene 1-chloro-2-cyclopropylbenzene 1-chloro-2-ethoxybenzene 1-chloro-2-fluoro-3-iodobenzene 1-chloro-2-fluoro-4-nitrobenzene 1-chloro-2-iodobenzene 1-chloro-2-isocyanatobenzene 1-chloro-2-isothiocyanatobenzene 1-chloro-2-methyl-3-nitrobenzene 1-chloro-2-nitrobenzene 1-chloro-2-phenoxybenzene 1-chloro-2-propoxybenzene 1-chloro-3,5-dimethylbenzene 1-chloro-3-(chloromethyl)benzene 1-chloro-3-(trifluoromethoxy)benzene 1-chloro-3-(trifluoromethyl)benzene 1-chloro-3-fluoro-2-methylbenzene 1-chloro-3-fluoro-2-nitrobenzene 1-chloro-3-iodo-2-methylbenzene 1-chloro-3-iodobenzene 1-chloro-3-methoxybenzene 1-chloro-3-nitrobenzene 1-chloro-3-phenoxybenzene 1-chloro-4-(trifluoromethoxy)benzene 1-chloro-4-iodobenzene 1-chloro-4-methoxybenzene 1-chloro-4-phenoxybenzene 1-chloroanthracene-9,10-dione 1-chloroisoquinoline 1-chloronaphthalene 2,3,5-trichloropyridine 2,3,6-trichloropyridine 2,3-dichloroaniline 2,3-dichlorobenzaldehyde 2,3-dichlorophenol 2,3-dichloropyridine 2,4,5-trichloropyrimidine 2,4,6-trichloropyridine 2,4,6-trichloropyrimidine 2,4-dibromo-1-chlorobenzene 2,4-dichloro-1-fluorobenzene 2,4-dichloro-1-methoxybenzene 2,4-dichloro-1-nitrobenzene 2,4-dichloro-6-methylpyridine 2,4-dichloro-6-methylpyrimidine 2,4-dichlorobenzaldehyde 2,4-dichlorobenzonitrile 2,4-dichloropyridine 2,4-dichloroquinazoline 2,4-dichlorothiazole 2,5-dichlorophenol 2,5-dichloropyrazine 2,5-dichloropyridine 2,6-dichloro-3-fluoropyridine 2,6-dichloro-3-methylpyridine 2,6-dichloro-3-nitropyridine 2,6-dichloro-4-methylpyridine 2,6-dichloroaniline 2,6-dichlorobenzoic acid 2,6-dichlorobenzonitrile 2,6-dichloronicotinonitrile 2,6-dichlorophenol 2,6-dichloropyrazine 2,6-dichloropyridin-3-amine 2,6-dichloropyridine 2-(2-chlorophenyl)acetic acid 2-(2-chlorophenyl)acetonitrile 2-(2-chlorophenyl)ethan-1-ol 2-(2-chlorophenyl)pyridine 2-(2-chlorophenyl)pyrrolidine 2-(3-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(3-chlorophenyl)acetonitrile 2-(4-chlorophenoxy)acetic acid 2-(chloromethyl)-1h-benzo[d]imidazole 2-(chloromethyl)-3-methylpyridine 2-(chloromethyl)furan 2-(chloromethyl)pyridine 2-(chloromethyl)pyridine 1-oxide 2-(chloromethyl)pyrimidine 2-(chloromethyl)thiazole 2-amino-3-chlorobenzoic acid 2-amino-3-chlorobenzonitrile 2-amino-6-chlorophenol 2-bromo-1,3-dichlorobenzene 2-bromo-1,4-dichlorobenzene 2-bromo-1-chloro-4-methylbenzene 2-bromo-4-chloro-1-iodobenzene 2-bromo-4-chloro-1-methoxybenzene 2-bromo-4-chloro-1-methylbenzene 2-bromo-4-chloroaniline 2-bromo-4-chlorophenol 2-bromo-6-chloroaniline 2-bromo-6-chlorophenol 2-chloro-1,1'-biphenyl 2-chloro-1,3,5-triazine 2-chloro-1,3-difluorobenzene 2-chloro-1,3-dimethoxybenzene 2-chloro-1,3-dinitrobenzene 2-chloro-1,4-difluorobenzene 2-chloro-1,4-dimethoxybenzene 2-chloro-1-fluoro-4-nitrobenzene 2-chloro-1-methyl-3-nitrobenzene 2-chloro-1-phenylethan-1-one 2-chloro-1h-benzo[d]imidazole 2-chloro-3,6-dimethylpyridine 2-chloro-3-(trifluoromethyl)aniline 2-chloro-3-(trifluoromethyl)pyridine 2-chloro-3-fluoropyridin-4-amine 2-chloro-3-hydroxybenzaldehyde 2-chloro-3-methoxypyridine 2-chloro-3-methylaniline 2-chloro-3-methylbenzoic acid 2-chloro-3-methylbenzonitrile 2-chloro-3-methylpyrazine 2-chloro-3-methylpyridine 2-chloro-3-nitropyridine 2-chloro-4,6-dimethylpyridine 2-chloro-4-(trifluoromethyl)pyridine 2-chloro-4-ethoxypyridine 2-chloro-4-fluoro-1-nitrobenzene 2-chloro-4-fluoroaniline 2-chloro-4-fluoropyridine 2-chloro-4-methoxypyridine 2-chloro-4-methyl-1-nitrobenzene 2-chloro-4-methylaniline 2-chloro-4-methylbenzoic acid 2-chloro-4-methylpyridine 2-chloro-4-methylpyrimidine 2-chloro-4-methylthiazole 2-chloro-4-phenylpyrimidine 2-chloro-5-(trifluoromethyl)pyridine 2-chloro-5-fluoropyridin-4-amine 2-chloro-5-fluoropyridine 2-chloro-5-methoxyaniline 2-chloro-5-methylpyridine 2-chloro-5-methylpyrimidine 2-chloro-5-methylthiazole 2-chloro-5-nitropyridine 2-chloro-6-(trifluoromethyl)aniline 2-chloro-6-(trifluoromethyl)pyridine 2-chloro-6-fluoroaniline 2-chloro-6-fluorophenol 2-chloro-6-fluoropyridine 2-chloro-6-iodophenol 2-chloro-6-methoxyaniline 2-chloro-6-methoxyphenol 2-chloro-6-methoxypyridine 2-chloro-6-methyl-3-nitropyridine 2-chloro-6-methylaniline 2-chloro-6-methylnicotinonitrile 2-chloro-6-methylphenol 2-chloro-6-methylpyrazine 2-chloro-6-methylpyridine 2-chloro-6-nitroaniline 2-chloro-7h-purine 2-chloro-7h-pyrrolo[2,3-d]pyrimidine 2-chloro-9h-purine 2-chloro-n-phenylacetamide 2-chloro-n-phenylaniline 2-chloroaniline 2-chlorobenzamide 2-chlorobenzene-1,3-diamine 2-chlorobenzene-1,3-diol 2-chlorobenzene-1,4-diamine 2-chlorobenzenesulfonyl chloride 2-chlorobenzenethiol 2-chlorobenzo[d]oxazole 2-chlorobenzo[d]thiazole 2-chlorobenzoic acid 2-chlorobenzonitrile 2-chlorobenzoyl chloride 2-chlorocyclohexa-2,5-diene-1,4-dione 2-chlorofuran 2-chloroisonicotinaldehyde 2-chloroisonicotinic acid 2-chloroisonicotinonitrile 2-chloronaphthalene 2-chloronicotinic acid 2-chloronicotinonitrile 2-chlorooxazole 2-chlorophenol 2-chloropyrazine 2-chloropyridin-3-amine 2-chloropyridin-3-ol 2-chloropyridin-4-amine 2-chloropyridine 1-oxide 2-chloroquinoxaline 2-chlorothiazole 2-chlorothiophene 3,4-dichloroaniline 3,5-dichloropyridine 3,6-dichloropyridazine 3-(3-chlorophenyl)propanoic acid 3-(chloromethyl)pyridine 3-chloro-1,1'-biphenyl 3-chloro-1-methyl-1h-pyrazole 3-chloro-1-phenylpropan-1-one 3-chloro-1h-indazole 3-chloro-2-fluoroaniline 3-chloro-2-fluorobenzaldehyde 3-chloro-2-fluorobenzoic acid 3-chloro-2-fluorobenzonitrile 3-chloro-2-fluoropyridine 3-chloro-2-hydroxybenzaldehyde 3-chloro-2-methoxypyridine 3-chloro-2-methylaniline 3-chloro-2-methylpyridine 3-chloro-2-nitroaniline 3-chloro-4-(trifluoromethyl)aniline 3-chloro-4-fluoroaniline 3-chloro-4-fluorobenzoic acid 3-chloro-4-hydroxybenzaldehyde 3-chloro-4-methylaniline 3-chloro-4-methylpyridazine 3-chloro-4-nitroaniline 3-chloro-5-fluoropyridine 3-chloro-5-methylpyridine 3-chloro-5-nitropyridine 3-chloro-9h-carbazole 3-chlorobenzaldehyde 3-chlorobenzene-1,2-diamine 3-chlorobenzene-1,2-diol 3-chlorobenzenesulfonyl chloride 3-chlorobenzo[b]thiophene 3-chlorobenzoic acid 3-chlorobenzonitrile 3-chloroimidazo[1,2-a]pyridine 3-chloroisoquinoline 3-chlorophenol 3-chloropicolinic acid 3-chloropicolinonitrile 3-chloropyridazine 3-chloropyridin-2-amine 3-chloropyridin-2-ol 3-chlorothiophene 4,5-dichloropyrimidine 4,6-dichloro-2-methylpyrimidine 4,6-dichloropyridin-2-amine 4,6-dichloropyridin-3-amine 4,6-dichloropyrimidine 4-chloro-1,5-naphthyridine 4-chloro-1-phenylbutan-1-one 4-chloro-1h-indazole 4-chloro-1h-indole 4-chloro-1h-pyrazole 4-chloro-1h-pyrazolo[3,4-b]pyridine 4-chloro-1h-pyrazolo[3,4-d]pyrimidine 4-chloro-1h-pyrazolo[4,3-c]pyridine 4-chloro-1h-pyrrolo[3,2-c]pyridine 4-chloro-2,6-dimethylpyridine 4-chloro-2-methoxypyridine 4-chloro-2-phenylpyrimidine 4-chloro-3-fluoroaniline 4-chloro-3-methylaniline 4-chloro-3-methylpyridine 4-chloro-5-methylpyrimidine 4-chloro-n-phenylaniline 4-chlorobenzene-1,3-diol 4-chlorobenzenesulfonic acid 4-chlorobenzenesulfonyl chloride 4-chlorobenzo[d]thiazole 4-chloroindoline-2,3-dione 4-chloroisoquinoline 4-chloronicotinic acid 4-chloropyridazine 4-chloropyridin-2-amine 4-chloropyridine 4-chloroquinazoline 5,6-dichloro-1h-benzo[d]imidazole 5,6-dichloropyridin-2-amine 5-bromo-4-chloropyrimidine 5-chloro-1,2,3,4-tetrahydroisoquinoline 5-chloro-1h-imidazole 5-chloro-1h-indazole 5-chloro-1h-indole 5-chloro-1h-indole-2-carboxylic acid 5-chloro-1h-pyrazole 5-chloro-1h-pyrazolo[4,3-b]pyridine 5-chloro-1h-pyrrolo[2,3-b]pyridine 5-chloro-1h-pyrrolo[3,2-b]pyridine 5-chloro-2,3-dihydrobenzofuran 5-chloro-2-fluoropyridine 5-chloro-2-methoxypyridine 5-chloro-2-methylpyridine 5-chlorobenzo[b]thiophene 5-chlorobenzo[d]oxazole 5-chlorobenzo[d]thiazole 5-chloroimidazo[1,2-a]pyridine 5-chloroindolin-2-one 5-chloroisoquinoline 5-chloropicolinic acid 5-chloropicolinonitrile 5-chloropyrazolo[1,5-a]pyrimidine 5-chloropyridin-2-amine 5-chloropyridin-2-ol 5-chloropyridin-3-amine 5-chloropyrimidine 5-chloroquinazoline 6-chloro-1,2,3,4-tetrahydroisoquinoline 6-chloro-1,2,3,4-tetrahydroquinoline 6-chloro-1h-benzo[d]imidazole 6-chloro-1h-indazole 6-chloro-1h-indole 6-chloro-1h-pyrazolo[4,3-c]pyridine 6-chloro-1h-pyrrolo[2,3-b]pyridine 6-chloro-1h-pyrrolo[3,2-c]pyridine 6-chloro-2,3-dihydrobenzofuran 6-chloro-3,4-dihydro-2h-benzo[b][1,4]oxazine 6-chloro-3-nitropyridin-2-amine 6-chloro-5-(trifluoromethyl)pyridin-2-amine 6-chlorobenzo[d]oxazole 6-chlorobenzo[d]thiazole 6-chlorochroman-4-one 6-chlorochromane 6-chloroindoline 6-chloroindoline-2,3-dione 6-chloronicotinaldehyde 6-chloronicotinic acid 6-chloropicolinic acid 6-chloropicolinonitrile 6-chloropyridazin-3(2h)-one 6-chloropyridin-2-amine 6-chloropyridin-2-ol 6-chloropyridin-3-amine 6-chloropyridine-3-sulfonyl chloride 6-chloroquinoxaline 7-chloro-1,2,3,4-tetrahydroisoquinoline 7-chloro-1h-indazole 7-chloro-1h-indole 7-chloro-1h-pyrrolo[2,3-c]pyridine 7-chloro-2,3-dihydrobenzofuran 7-chloro-3,4-dihydronaphthalen-1(2h)-one 7-chlorobenzo[d]thiazole 7-chlorochromane 7-chloroisoquinoline 7-chloropyrazolo[1,5-a]pyrimidine 8-chlorochromane 8-chloroimidazo[1,2-a]pyridine 8-chloroisoquinoline 8-chloroquinazoline Ethyl 4,6-dichloronicotinate Ethyl 5-chloro-1h-indole-2-carboxylate Ethyl 6-chloropicolinate Ethyl 7-chloro-1h-indole-2-carboxylate Methyl 2,6-dichlorobenzoate Methyl 2-chloro-4-fluorobenzoate Methyl 2-chloro-6-fluorobenzoate Methyl 2-chlorobenzoate Methyl 2-chloroisonicotinate Methyl 2-chloronicotinate Methyl 3-chlorobenzoate Methyl 3-chloropicolinate Methyl 6-chloropicolinate N-(2-chlorophenyl)acetamide N-(3-chlorophenyl)benzenesulfonamide N-(3-chlorophenyl)quinazolin-4-amine N-(4-chlorophenyl)acetamide Phenyl carbonochloridate Pyridine-2-sulfonyl chloride Pyridine-3-sulfonyl chloride Tert-butyl (2-chloropyridin-4-yl)carbamate

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2,2,2-trichloro-ethanone 2-chloro-n-acetamide 2-chloro-n-methyl-acetamide 2-chloro-n-methylacetamide 2-chloroacetyl 2-chloroethyl 3-chloro-1-propanone 3-chloro-propanamide 3-chloropropyl 4-chloro-butan-1-one 4-chlorobutyl Benzothiazole-chloride Benzoxazole-chloride Bromo-chloro-benzene Carbonochloridate Chlorindole-carboxylic acid Chlorindole-carboxylic-acid Chloro-benzimidazole Chloro-benzoxazine Chloro-carbazole Chloro-fluoro-benzene Chloro-imidazopyridine Chloro-indazole Chloro-indazole-carboxylate Chloro-inden-amine Chloro-inden-one Chloro-indene Chloro-indole-carboxylate Chloro-iodo-trifluoromethyl-pyridine Chloro-methyl indole Chloro-methyl-indazole Chloro-methyl-pyrazole Chloro-naphthyridin-one Chloro-naphthyridine Chloro-nitrobenzene Chloro-one Chloro-phenyl-boronic-acid Chloro-propylamine-hydrochloride Chloro-purine Chloro-pyrazolamide Chloro-pyrazole Chloro-pyrazole-carboxylate Chloro-pyrazolopyridine Chloro-pyrrolopyridine Chloro-pyrrolopyrimidine Chloro-thiadiazole Chloro-trifluoromethyl-pyridin-amine Chloro-trifluoromethyl-pyridine Chloroacetamide Chloroacetyl Chloroaniline Chlorobenzaldehyde Chlorobenzamide Chlorobenzene Chlorobenzenesulfonamide Chlorobenzofuran Chlorobenzothiazole Chlorobenzotrifluoride Chlorobenzyl Chlorobutyl Chlorobutyl Chlorocarbonyl Chlorochroman Chloroethoxy Chloroethoxy Chloroethyl Chloroethylamino Chloroimidazo Chloroindole Chloroisobenzofuran Chloromethyl Chloromethylbutyl Chlorooxazole Chlorophenyl Chlorophthalazin Chloropicolinaldehyde Chloropicolinamide Chloropropane Chloropropane Chloropropoxy Chloropropoxy Chloropropyl Chloropyrazine Chloropyridazine Chloropyridine Chloropyrimidine Chloroquinazoline Chloroquinoline Chloroquinoxaline Chlorotoluene Dichloride Dichloro Dichloroaniline Dichloroanthracene Dichlorobenzaldehyde Dichlorobenzamide Dichlorobenzenesulfonamide Dichloroisonicotinaldehyde Dichloromethyl Dichloromethyl Dichloronicotinaldehyde Dichloronicotinate Dichloronicotinic Dichloronicotinic Dichloronicotinic acid Dichloropalladium Dichloropalladium Dichloropyridazine Dichloropyrimidine Dichloroquinoline Nicotinoyl-chloride Tetrachloro Tetrachloro Tetrahydroisoquinoline-chloride Tetrahydroquinoline-chloride Trichloride Trichloro Trichloro Trichloroacetimidate Trichloroaniline Trichlorobenzaldehyde Trichloroethyl Trichloroethyl Trichloromethyl Trichloromethyl

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