Home Chemistry Heterocyclic Building Blocks Pyrans Isochromane
Electrophilic Aromatic Substitution (EAS): Isochromane, like other aromatic compounds, can undergo electrophilic aromatic substitution reactions. In this type of reaction, an electrophile (electron-deficient species) replaces a hydrogen atom on the aromatic ring. The mechanism and regioselectivity would depend on the specific conditions and reagents used.
Nucleophilic Aromatic Substitution (NAS): Although less common, nucleophilic aromatic substitution reactions are possible, particularly under certain conditions. This involves the replacement of a leaving group attached to the aromatic ring by a nucleophile.
Redox Reactions: Isochromane can undergo redox reactions, either through direct reaction with strong oxidizing or reducing agents, or in more complex reactions involving electron transfer.
Metalation Reactions: Isochromane, being aromatic, can potentially serve as a ligand in coordination chemistry. It can form complexes with transition metals through donation of its electron density to the metal center.
Ring-Opening Reactions: Isochromane can undergo ring-opening reactions under certain conditions, especially if it is activated by electron-withdrawing or electron-donating groups.
Substitution Reactions: Depending on the substituents present on the isochromane ring, various substitution reactions can occur. For example, if there are reactive functional groups, they may undergo substitution reactions.
Halogenation Reactions: Isochromane can potentially undergo halogenation reactions, where halogen atoms replace hydrogen atoms on the aromatic ring.
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