Home Chemistry Organic building blocks Bromides 1-bromo-4-fluoro-2-methoxybenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—OCH3,—F).
Suzuki-Miyaura Coupling: Bromobenzene can participate in cross-coupling reactions with organoboron compounds in the presence of a palladium catalyst, resulting in the formation of biaryl compounds.
Wacker Oxidation: Methoxybenzene can undergo the Wacker oxidation using palladium chloride and copper chloride to form the corresponding ketone.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
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1-Bromo-4-fluoro-5-isopropyl-2-methoxybenzene
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(5-Bromo-2,3-difluoro-4-methoxyphenyl)boronic acid
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(3-Bromo-6-fluoro-2-methoxyphenyl)boronic acid
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1-Bromo-4-fluoro-2-methoxy-5-nitrobenzene
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