Home Chemistry Heterocyclic Building Blocks Quinazolines 5,6,7,8-Tetrahydroquinazoline
Amination: The nitrogen atoms in the quinazoline ring can be aminated, meaning they can undergo reactions with aminating agents to introduce new amino groups. For example, you can react it with ammonia or amine compounds to form substituted derivatives.
Alkylation: The nitrogen atoms can also be alkylated, which involves adding alkyl groups to the nitrogen atoms. This can be done using alkyl halides or other alkylating agents.
Ring Opening: Depending on the reaction conditions and reagents used, ring-opening reactions can occur. For instance, under certain conditions, you can open up the quinazoline ring to form open-chain compounds.
Reduction: The unsaturated bonds within the quinazoline ring can be reduced. This can be achieved with reducing agents like hydrogen gas and a catalyst or with chemical reducing agents.
Oxidation: The compound can be oxidized to form compounds with more oxygen-containing functional groups. Oxidizing agents like potassium permanganate or chromium(VI) reagents can be used for this purpose.
Substitution Reactions: Other substitution reactions can occur at various positions on the ring system depending on the reagents and reaction conditions. Substituents can be added or replaced.
Condensation Reactions: 5,6,7,8-Tetrahydroquinazoline can participate in condensation reactions with other compounds, leading to the formation of larger, more complex molecules.
Cyclization: Intramolecular cyclization reactions can occur to form different cyclic structures if suitable conditions are provided.
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2-Methyl-5,6,7,8-tetrahydroquinazolin-4-ol
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2,4-Dichloro-5,6,7,8-tetrahydroquinazoline-6-carboxylic acid
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2-(Methylthio)-5,6,7,8-tetrahydroquinazoline-6-carboxylic acid
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2,4-Dichloro-5,6,7,8-tetrahydroquinazoline
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4-Chloro-2-(methylthio)-5,6,7,8-tetrahydroquinazoline
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