Home Chemistry Heterocyclic Building Blocks Pyridines 2-Bromo-6-Fluoropyridine
Nucleophilic Substitution: The bromine atom is a good leaving group, so reactions such as substitution with a nucleophile can occur. For instance, it can undergo substitution reactions with a variety of nucleophiles such as amines, thiols, or cyanide ions.
Cross-Coupling Reactions: 2-bromo-6-fluoropyridine can undergo cross-coupling reactions, such as Suzuki-Miyaura coupling or Stille coupling, which are useful in forming carbon-carbon bonds. In these reactions, the bromine atom can be replaced by an organometallic reagent, leading to the formation of biaryl compounds.
Metalation Reactions: The bromine atom can be deprotonated by strong bases like butyllithium or Grignard reagents to generate a pyridine derivative with a metal attached. This intermediate can subsequently react with various electrophiles.
Reductive Reactions: The bromine atom can be substituted with hydrogen under appropriate conditions, such as catalytic hydrogenation or reduction with metal hydrides like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Functional Group Transformations: The compound can undergo various transformations, such as halogenation, oxidation, or reduction of other functional groups present on the molecule.
Electrophilic Aromatic Substitution: In certain conditions, the pyridine ring can undergo electrophilic aromatic substitution reactions where the bromine atom serves as a directing group.
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2-Bromo-6-fluoro-5-methylpyridin-3-amine
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