Home Chemistry Heterocyclic Building Blocks Indazoles 6-Methyl-1H-Indazole
Electrophilic substitution: The electron-rich aromatic system of 6-methyl-1H-indazole can undergo electrophilic substitution reactions, such as nitration, halogenation, sulfonation, or Friedel-Crafts acylation/alkylation.
Nucleophilic substitution: The nitrogen atom in the indazole ring can undergo nucleophilic substitution reactions with various electrophiles, leading to the formation of substituted derivatives.
Ring-Opening Reactions: The indazole ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Oxidation: The methyl group or the nitrogen atom in the indazole ring can be oxidized under appropriate conditions to form corresponding oxidation products.
Reduction: Functional groups within the molecule, such as nitro, carbonyl, or azide groups, can be reduced to their respective amine or alcohol derivatives using reducing agents.
Cyclization Reactions: 6-methyl-1H-indazole can participate in various cyclization reactions with appropriate reagents to form cyclic compounds with different ring sizes.
Amidation: The nitrogen atom can react with carboxylic acids or acid derivatives to form amides.
Halogenation: The methyl group can undergo halogenation reactions under suitable conditions to form halomethyl derivatives.
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(6-Methyl-1H-indazol-5-yl)boronic acid
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