Home Chemistry Heterocyclic Building Blocks Thiazolidines 2-Thioxothiazolidin-4-One
Michael Addition: 2-thioxothiazolidin-4-one can undergo Michael addition reactions with nucleophiles. This is especially true for compounds containing active methylene groups (like malonates or β-ketoesters). The reaction proceeds through the attack of the nucleophile on the β-carbon, leading to the formation of a new C-C bond.
Cyclization Reactions: Depending on the reagents and conditions, 2-thioxothiazolidin-4-one can undergo various cyclization reactions to form different heterocyclic compounds. For example, reaction with amines can lead to the formation of imidazolidine derivatives.
Substitution Reactions: The chlorine atom in the 2-position of 2-thioxothiazolidin-4-one can undergo nucleophilic substitution reactions.
Condensation Reactions: It can undergo condensation reactions with various carbonyl compounds or amines to form a variety of products.
Ring Opening Reactions: Depending on the conditions, 2-thioxothiazolidin-4-one can undergo ring-opening reactions to form compounds with a linear structure.
Alkylation and Acylation: The nitrogen atom in 2-thioxothiazolidin-4-one can be alkylated or acylated to form new derivatives.
Photocycloaddition Reactions: Depending on the substituents and reaction conditions, 2-thioxothiazolidin-4-one can participate in photochemical cycloaddition reactions.
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3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid
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2-(4-Oxo-2-thioxothiazolidin-3-yl)succinic acid
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2-(4-Oxo-2-thioxothiazolidin-3-yl)acetic acid
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