Home Chemistry Heterocyclic Building Blocks Thiadiazoles 1,2,5-Thiadiazole
Ring Opening Reactions: 1,2,5-thiadiazole can undergo ring-opening reactions under certain conditions, leading to the formation of different compounds. For example, treatment with strong bases or nucleophiles can lead to the opening of the ring and the generation of various products.
Substitution Reactions: The sulfur atom in 1,2,5-thiadiazole can be substituted with various functional groups or other nucleophiles. For instance, you can perform nucleophilic substitution reactions to replace the sulfur atom with another atom or group.
Acylation: 1,2,5-thiadiazole can be acylated by reaction with acyl chlorides or anhydrides in the presence of a suitable base or catalyst. This can lead to the introduction of acyl groups into the molecule.
Nitration: Nitration of 1,2,5-thiadiazole can be carried out by treating it with nitric acid. This can lead to the introduction of nitro groups into the molecule.
Cyclization: 1,2,5-thiadiazole can participate in various intramolecular cyclization reactions to form fused or bridged heterocyclic compounds.
Metal Complexation: It can form coordination complexes with metal ions due to its ability to act as a bidentate ligand, where both the nitrogen atoms can coordinate with a metal center.
Condensation Reactions: 1,2,5-thiadiazole can participate in condensation reactions with carbonyl compounds, leading to the formation of Schiff bases or related compounds.
Biological Reactions: 1,2,5-thiadiazole derivatives have been studied for their biological activity, including their potential as pharmaceuticals. Various bioconjugation and modification reactions can be applied to these derivatives to enhance their bioavailability and target specificity.
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Methyl 4-amino-1,2,5-thiadiazole-3-carboxylate
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Methyl 4-bromo-1,2,5-thiadiazole-3-carboxylate
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4-Amino-1,2,5-thiadiazole-3-carboxylic acid
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