Home Chemistry Heterocyclic Building Blocks Azetidines 3-Phenylazetidine
Ring-Opening Reactions: Azetidines can undergo ring-opening reactions with various nucleophiles, such as amines, alcohols, and thiols, to form open-chain compounds.
Reduction: Like other nitrogen-containing heterocycles, azetidines can be reduced using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) to yield corresponding amines.
N-Alkylation: Azetidines can be N-alkylated using alkyl halides or other suitable alkylating agents in the presence of a base to form N-alkylazetidines.
Cycloaddition Reactions: Depending on the substituents present, azetidines can participate in various cycloaddition reactions, such as Diels-Alder reactions, to form fused-ring compounds.
Functional Group Transformations: Various functional group transformations can be carried out on 3-phenylazetidine, including oxidation, reduction, and substitution reactions.
Ring-Closing Reactions: Azetidines can be subjected to ring-closing reactions under suitable conditions to form cyclic compounds with different ring sizes.
Hofmann Rearrangement: Azetidines can undergo Hofmann rearrangement under specific conditions to produce primary amines.
Photochemical Reactions: Azetidines can also participate in photochemical reactions when exposed to suitable wavelengths of light, leading to various photoproducts.
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