The ASGPR (asialoglycoprotein receptor) is a receptor located on the surface of liver cells, specialized in recognizing and binding molecules with specific sugar structures, thereby facilitating their phagocytosis and clearance. This receptor family is composed of several subunits that work together to bind their targets with high affinity. ASGPR is specifically expressed in the liver and plays a key role in maintaining the homeostasis of serum glycoproteins. Through endocytosis, ASGPR regulates protein metabolism and the clearance of waste glycoproteins from the circulation. Genetic variations can affect the expression or function of the receptor, thereby impacting the liver's clearance capacity and sometimes being associated with the development of certain liver diseases.