Home Chemistry Heterocyclic Building Blocks Indoles Tert-Butyl 3-(Hydroxymethyl)-1H-Indole-1-Carboxylate
Ester Hydrolysis: Like many esters , tert-butyl 3-(hydroxymethyl)-1H-indole-1-carboxylate can undergo hydrolysis reactions under acidic or basic conditions to produce the corresponding carboxylic acid and alcohol
Esterification: The carboxylate group can participate in esterification reactions with alcohols to form ester compounds.
Oxidation Reactions: The tertiary butyl group is relatively resistant to oxidation, but the hydroxymethyl group may undergo oxidation under certain conditions.
Decarboxylation: The carboxylate group may undergo decarboxylation reactions under specific conditions, leading to the removal of the carboxyl group.
Cyclization Reactions: The indole ring can participate in various cyclization reactions, leading to the formation of fused or spirocyclic structures.
Substitution Reactions: The indole ring may undergo substitution reactions, especially if activated by electron-donating or withdrawing groups.
Protecting Group Manipulations: The tert-butyl group may serve as a protecting group for the carboxylic acid, and selective removal of this group can be achieved under specific conditions.
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