Home Chemistry Heterocyclic Building Blocks Indoles Tert-Butyl 1H-Indole-1-Carboxylate
Ester Hydrolysis: Tert-butyl 1H-indole-1-carboxylate contains an ester functional group. ester hydrolysis, under acidic or basic conditions, can lead to the formation of the corresponding carboxylic acid and alcohol.
Nucleophilic Substitution: The tert-butyl group can be a site for nucleophilic substitution reactions. the indole ring, being aromatic, might also participate in nucleophilic aromatic substitution reactions under certain conditions.
Reduction Reactions: The carbonyl group in the ester can undergo reduction to form the corresponding alcohol. This reduction can be achieved using various reducing agents.
Nucleophilic Addition: The indole ring can participate in nucleophilic addition reactions, especially at the C-3 position. This may involve reactions with electrophiles.
Cyclization Reactions: Depending on the conditions, the compound might undergo intramolecular cyclization reactions. This could result in the formation of fused or spirocyclic structures.
Amide Formation: The carboxylate group in the ester can react with amines or ammonia to form amides under appropriate conditions.
Halogenation: The aromatic ring in the indole ring moiety might undergo halogenation reactions, such as electrophilic aromatic substitution.
Oxidation Reactions: The tert-butyl group, being an alkyl group, may undergo oxidation reactions under certain conditions.
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tert-Butyl 2-bromo-1H-indole-1-carboxylate
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tert-Butyl 7-(bromomethyl)-1H-indole-1-carboxylate
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tert-Butyl 6-(hydroxymethyl)-1H-indole-1-carboxylate
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tert-Butyl 6-formyl-1H-indole-1-carboxylate
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tert-Butyl 6-(chloromethyl)-1H-indole-1-carboxylate
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1-(tert-Butoxycarbonyl)-1H-indol-5-ylboronic acid pinacol ester
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tert-Butyl 5-formyl-1H-indole-1-carboxylate
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tert-Butyl 3-(2-cyanopropan-2-yl)-1H-indole-1-carboxylate
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tert-Butyl 3-(1-amino-2-methylpropan-2-yl)-1H-indole-1-carboxylate
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1-tert-Butyl 2-methyl 1H-indole-1,2-dicarboxylate
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(1-(tert-Butoxycarbonyl)-1H-indol-4-yl)boronic acid
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tert-Butyl 3-Bromomethyl-indole-1-carboxylate
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