Chemistry Organic Building Blocks Chlorides 3-Chloro-2-Fluoroaniline

3-Chloro-2-Fluoroaniline

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—F,—NH2).

Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Reimer-Tiemann Reaction: Aniline can react with chloroform (CHCl3) and a base to undergo the Reimer-Tiemann reaction, leading to the formation of a salicylaldehyde derivative.

Further Reading:

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(2,3-Dichlorophenyl)Boronic Acid (2,6-Dichlorophenyl)Boronic Acid (2-Chloroethoxy)Benzene (2-Chlorophenyl)(Phenyl)Methanone (2-Chlorophenyl)Hydrazine (2-Chlorophenyl)Methanamine (2-Chlorophenyl)Methanol (2-Chloropyridin-4-Yl)Boronic Acid (3,4-Dichlorophenyl)Boronic Acid (3-Chloro-4-Fluorophenyl)Boronic Acid (3-Chlorophenyl)(Phenyl)Methanone (3-Chlorophenyl)Boronic Acid (3-Chlorophenyl)Hydrazine (3-Chlorophenyl)Methanamine (3-Chlorophenyl)Methanol (3-Chloropyridin-2-Yl)Methanamine (4-Chlorophenyl)(Phenyl)Methanone (5-Chloropyridin-2-Yl)Methanamine (Chloromethanetriyl)Tribenzene (Chloromethylene)Dibenzene 1,2,3,4-Tetrachlorobenzene 1,2,4-Trichlorobenzene 1,2-Dibromo-3-Chlorobenzene 1,2-Dichloro-3-Fluorobenzene 1,2-Dichloro-3-Methoxybenzene 1,2-Dichloro-3-Methylbenzene 1,2-Dichloro-4-Fluorobenzene 1,2-Dichloro-4-Methoxybenzene 1,2-Dichloro-4-Nitrobenzene 1,3-Dibromo-2-Chlorobenzene 1,3-Dichloro-2-Fluorobenzene 1,3-Dichloro-2-Iodobenzene 1,3-Dichloro-2-Methoxybenzene 1,3-Dichloro-2-Nitrobenzene 1,3-Dichloroisoquinoline 1,4-Dichloro-2-Fluorobenzene 1,4-Dichloro-2-Methoxybenzene 1-(2-Chlorophenyl)Ethan-1-One 1-(2-Chlorophenyl)Piperazine 1-(3-Chlorophenyl)-1H-Pyrazole 1-(3-Chlorophenyl)-N-Methylmethanamine 1-(3-Chlorophenyl)Ethan-1-One 1-(3-Chlorophenyl)Pyrrolidine 1-(Benzyloxy)-2-Chlorobenzene 1-(Benzyloxy)-3-Chlorobenzene 1-(Bromomethyl)-2-Chlorobenzene 1-(Bromomethyl)-3-Chlorobenzene 1-(Chloromethyl)-2-Methylbenzene 1-Benzyl-2-Chlorobenzene 1-Benzyl-3-Chlorobenzene 1-Benzyl-4-Chlorobenzene 1-Bromo-2,3-Dichlorobenzene 1-Bromo-2-Chloro-3-Methylbenzene 1-Bromo-3-Chloro-2-Fluorobenzene 1-Bromo-3-Chloro-2-Methylbenzene 1-Bromo-4-Chloro-2-Fluorobenzene 1-Chloro-2,3-Difluorobenzene 1-Chloro-2,4-Difluorobenzene 1-Chloro-2,4-Dimethoxybenzene 1-Chloro-2-(Chloromethyl)Benzene 1-Chloro-2-(Trifluoromethoxy)Benzene 1-Chloro-2-(Trifluoromethyl)Benzene 1-Chloro-2-Cyclopropylbenzene 1-Chloro-2-Ethoxybenzene 1-Chloro-2-Fluoro-3-Iodobenzene 1-Chloro-2-Fluoro-4-Nitrobenzene 1-Chloro-2-Iodobenzene 1-Chloro-2-Isocyanatobenzene 1-Chloro-2-Isothiocyanatobenzene 1-Chloro-2-Methyl-3-Nitrobenzene 1-Chloro-2-Nitrobenzene 1-Chloro-2-Phenoxybenzene 1-Chloro-2-Propoxybenzene 1-Chloro-3,5-Dimethylbenzene 1-Chloro-3-(Chloromethyl)Benzene 1-Chloro-3-(Trifluoromethoxy)Benzene 1-Chloro-3-(Trifluoromethyl)Benzene 1-Chloro-3-Fluoro-2-Methylbenzene 1-Chloro-3-Fluoro-2-Nitrobenzene 1-Chloro-3-Iodo-2-Methylbenzene 1-Chloro-3-Iodobenzene 1-Chloro-3-Methoxybenzene 1-Chloro-3-Nitrobenzene 1-Chloro-3-Phenoxybenzene 1-Chloro-4-(Trifluoromethoxy)Benzene 1-Chloro-4-Iodobenzene 1-Chloro-4-Methoxybenzene 1-Chloro-4-Phenoxybenzene 1-Chloroanthracene-9,10-Dione 1-Chloroisoquinoline 1-Chloronaphthalene 2,3,5-Trichloropyridine 2,3,6-Trichloropyridine 2,3-Dichloroaniline 2,3-Dichlorobenzaldehyde 2,3-Dichlorophenol 2,3-Dichloropyridine 2,4,5-Trichloropyrimidine 2,4,6-Trichloropyridine 2,4,6-Trichloropyrimidine 2,4-Dibromo-1-Chlorobenzene 2,4-Dichloro-1-Fluorobenzene 2,4-Dichloro-1-Methoxybenzene 2,4-Dichloro-1-Nitrobenzene 2,4-Dichloro-6-Methylpyridine 2,4-Dichloro-6-Methylpyrimidine 2,4-Dichlorobenzaldehyde 2,4-Dichlorobenzonitrile 2,4-Dichloropyridine 2,4-Dichloroquinazoline 2,4-Dichlorothiazole 2,5-Dichlorophenol 2,5-Dichloropyrazine 2,5-Dichloropyridine 2,6-Dichloro-3-Fluoropyridine 2,6-Dichloro-3-Methylpyridine 2,6-Dichloro-3-Nitropyridine 2,6-Dichloro-4-Methylpyridine 2,6-Dichloroaniline 2,6-Dichlorobenzoic Acid 2,6-Dichlorobenzonitrile 2,6-Dichloronicotinonitrile 2,6-Dichlorophenol 2,6-Dichloropyrazine 2,6-Dichloropyridin-3-Amine 2,6-Dichloropyridine 2-(2-Chlorophenyl)Acetic Acid 2-(2-Chlorophenyl)Acetonitrile 2-(2-Chlorophenyl)Ethan-1-Ol 2-(2-Chlorophenyl)Pyridine 2-(2-Chlorophenyl)Pyrrolidine 2-(3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane 2-(3-Chlorophenyl)Acetonitrile 2-(4-Chlorophenoxy)Acetic Acid 2-(Chloromethyl)-1H-Benzo[D]Imidazole 2-(Chloromethyl)-3-Methylpyridine 2-(Chloromethyl)Furan 2-(Chloromethyl)Pyridine 2-(Chloromethyl)Pyridine 1-Oxide 2-(Chloromethyl)Pyrimidine 2-(Chloromethyl)Thiazole 2-Amino-3-Chlorobenzoic Acid 2-Amino-3-Chlorobenzonitrile 2-Amino-6-Chlorophenol 2-Bromo-1,3-Dichlorobenzene 2-Bromo-1,4-Dichlorobenzene 2-Bromo-1-Chloro-4-Methylbenzene 2-Bromo-4-Chloro-1-Iodobenzene 2-Bromo-4-Chloro-1-Methoxybenzene 2-Bromo-4-Chloro-1-Methylbenzene 2-Bromo-4-Chloroaniline 2-Bromo-4-Chlorophenol 2-Bromo-6-Chloroaniline 2-Bromo-6-Chlorophenol 2-Chloro-1,1'-Biphenyl 2-Chloro-1,3,5-Triazine 2-Chloro-1,3-Difluorobenzene 2-Chloro-1,3-Dimethoxybenzene 2-Chloro-1,3-Dinitrobenzene 2-Chloro-1,4-Difluorobenzene 2-Chloro-1,4-Dimethoxybenzene 2-Chloro-1-Fluoro-4-Nitrobenzene 2-Chloro-1-Methyl-3-Nitrobenzene 2-Chloro-1-Phenylethan-1-One 2-Chloro-1H-Benzo[D]Imidazole 2-Chloro-3,6-Dimethylpyridine 2-Chloro-3-(Trifluoromethyl)Aniline 2-Chloro-3-(Trifluoromethyl)Pyridine 2-Chloro-3-Fluoropyridin-4-Amine 2-Chloro-3-Hydroxybenzaldehyde 2-Chloro-3-Methoxypyridine 2-Chloro-3-Methylaniline 2-Chloro-3-Methylbenzoic Acid 2-Chloro-3-Methylbenzonitrile 2-Chloro-3-Methylpyrazine 2-Chloro-3-Methylpyridine 2-Chloro-3-Nitropyridine 2-Chloro-4,6-Dimethylpyridine 2-Chloro-4-(Trifluoromethyl)Pyridine 2-Chloro-4-Ethoxypyridine 2-Chloro-4-Fluoro-1-Nitrobenzene 2-Chloro-4-Fluoroaniline 2-Chloro-4-Fluoropyridine 2-Chloro-4-Methoxypyridine 2-Chloro-4-Methyl-1-Nitrobenzene 2-Chloro-4-Methylaniline 2-Chloro-4-Methylbenzoic Acid 2-Chloro-4-Methylpyridine 2-Chloro-4-Methylpyrimidine 2-Chloro-4-Methylthiazole 2-Chloro-4-Phenylpyrimidine 2-Chloro-5-(Trifluoromethyl)Pyridine 2-Chloro-5-Fluoropyridin-4-Amine 2-Chloro-5-Fluoropyridine 2-Chloro-5-Methoxyaniline 2-Chloro-5-Methylpyridine 2-Chloro-5-Methylpyrimidine 2-Chloro-5-Methylthiazole 2-Chloro-5-Nitropyridine 2-Chloro-6-(Trifluoromethyl)Aniline 2-Chloro-6-(Trifluoromethyl)Pyridine 2-Chloro-6-Fluoroaniline 2-Chloro-6-Fluorophenol 2-Chloro-6-Fluoropyridine 2-Chloro-6-Iodophenol 2-Chloro-6-Methoxyaniline 2-Chloro-6-Methoxyphenol 2-Chloro-6-Methoxypyridine 2-Chloro-6-Methyl-3-Nitropyridine 2-Chloro-6-Methylaniline 2-Chloro-6-Methylnicotinonitrile 2-Chloro-6-Methylphenol 2-Chloro-6-Methylpyrazine 2-Chloro-6-Methylpyridine 2-Chloro-6-Nitroaniline 2-Chloro-7H-Purine 2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine 2-Chloro-9H-Purine 2-Chloro-N-Phenylacetamide 2-Chloro-N-Phenylaniline 2-Chloroaniline 2-Chlorobenzamide 2-Chlorobenzene-1,3-Diamine 2-Chlorobenzene-1,3-Diol 2-Chlorobenzene-1,4-Diamine 2-Chlorobenzenesulfonyl Chloride 2-Chlorobenzenethiol 2-Chlorobenzo[D]Oxazole 2-Chlorobenzo[D]Thiazole 2-Chlorobenzoic Acid 2-Chlorobenzonitrile 2-Chlorobenzoyl Chloride 2-Chlorocyclohexa-2,5-Diene-1,4-Dione 2-Chlorofuran 2-Chloroisonicotinaldehyde 2-Chloroisonicotinic Acid 2-Chloroisonicotinonitrile 2-Chloronaphthalene 2-Chloronicotinic Acid 2-Chloronicotinonitrile 2-Chlorooxazole 2-Chlorophenol 2-Chloropyrazine 2-Chloropyridin-3-Amine 2-Chloropyridin-3-Ol 2-Chloropyridin-4-Amine 2-Chloropyridine 1-Oxide 2-Chloroquinoxaline 2-Chlorothiazole 2-Chlorothiophene 3,4-Dichloroaniline 3,5-Dichloropyridine 3,6-Dichloropyridazine 3-(3-Chlorophenyl)Propanoic Acid 3-(Chloromethyl)Pyridine 3-Chloro-1,1'-Biphenyl 3-Chloro-1-Methyl-1H-Pyrazole 3-Chloro-1-Phenylpropan-1-One 3-Chloro-1H-Indazole 3-Chloro-2-Fluoroaniline 3-Chloro-2-Fluorobenzaldehyde 3-Chloro-2-Fluorobenzoic Acid 3-Chloro-2-Fluorobenzonitrile 3-Chloro-2-Fluoropyridine 3-Chloro-2-Hydroxybenzaldehyde 3-Chloro-2-Methoxypyridine 3-Chloro-2-Methylaniline 3-Chloro-2-Methylpyridine 3-Chloro-2-Nitroaniline 3-Chloro-4-(Trifluoromethyl)Aniline 3-Chloro-4-Fluoroaniline 3-Chloro-4-Fluorobenzoic Acid 3-Chloro-4-Hydroxybenzaldehyde 3-Chloro-4-Methylaniline 3-Chloro-4-Methylpyridazine 3-Chloro-4-Nitroaniline 3-Chloro-5-Fluoropyridine 3-Chloro-5-Methylpyridine 3-Chloro-5-Nitropyridine 3-Chloro-9H-Carbazole 3-Chlorobenzaldehyde 3-Chlorobenzene-1,2-Diamine 3-Chlorobenzene-1,2-Diol 3-Chlorobenzenesulfonyl Chloride 3-Chlorobenzo[B]Thiophene 3-Chlorobenzoic Acid 3-Chlorobenzonitrile 3-Chloroimidazo[1,2-A]Pyridine 3-Chloroisoquinoline 3-Chlorophenol 3-Chloropicolinic Acid 3-Chloropicolinonitrile 3-Chloropyridazine 3-Chloropyridin-2-Amine 3-Chloropyridin-2-Ol 3-Chlorothiophene 4,5-Dichloropyrimidine 4,6-Dichloro-2-Methylpyrimidine 4,6-Dichloropyridin-2-Amine 4,6-Dichloropyridin-3-Amine 4,6-Dichloropyrimidine 4-Chloro-1,5-Naphthyridine 4-Chloro-1-Phenylbutan-1-One 4-Chloro-1H-Indazole 4-Chloro-1H-Indole 4-Chloro-1H-Pyrazole 4-Chloro-1H-Pyrazolo[3,4-B]Pyridine 4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 4-Chloro-1H-Pyrazolo[4,3-C]Pyridine 4-Chloro-1H-Pyrrolo[3,2-C]Pyridine 4-Chloro-2,6-Dimethylpyridine 4-Chloro-2-Methoxypyridine 4-Chloro-2-Phenylpyrimidine 4-Chloro-3-Fluoroaniline 4-Chloro-3-Methylaniline 4-Chloro-3-Methylpyridine 4-Chloro-5-Methylpyrimidine 4-Chloro-N-Phenylaniline 4-Chlorobenzene-1,3-Diol 4-Chlorobenzenesulfonic Acid 4-Chlorobenzenesulfonyl Chloride 4-Chlorobenzo[D]Thiazole 4-Chloroindoline-2,3-Dione 4-Chloroisoquinoline 4-Chloronicotinic Acid 4-Chloropyridazine 4-Chloropyridin-2-Amine 4-Chloropyridine 4-Chloroquinazoline 5,6-Dichloro-1H-Benzo[D]Imidazole 5,6-Dichloropyridin-2-Amine 5-Bromo-4-Chloropyrimidine 5-Chloro-1,2,3,4-Tetrahydroisoquinoline 5-Chloro-1H-Imidazole 5-Chloro-1H-Indazole 5-Chloro-1H-Indole 5-Chloro-1H-Indole-2-Carboxylic Acid 5-Chloro-1H-Pyrazole 5-Chloro-1H-Pyrazolo[4,3-B]Pyridine 5-Chloro-1H-Pyrrolo[2,3-B]Pyridine 5-Chloro-1H-Pyrrolo[3,2-B]Pyridine 5-Chloro-2,3-Dihydrobenzofuran 5-Chloro-2-Fluoropyridine 5-Chloro-2-Methoxypyridine 5-Chloro-2-Methylpyridine 5-Chlorobenzo[B]Thiophene 5-Chlorobenzo[D]Oxazole 5-Chlorobenzo[D]Thiazole 5-Chloroimidazo[1,2-A]Pyridine 5-Chloroindolin-2-One 5-Chloroisoquinoline 5-Chloropicolinic Acid 5-Chloropicolinonitrile 5-Chloropyrazolo[1,5-A]Pyrimidine 5-Chloropyridin-2-Amine 5-Chloropyridin-2-Ol 5-Chloropyridin-3-Amine 5-Chloropyrimidine 5-Chloroquinazoline 6-Chloro-1,2,3,4-Tetrahydroisoquinoline 6-Chloro-1,2,3,4-Tetrahydroquinoline 6-Chloro-1H-Benzo[D]Imidazole 6-Chloro-1H-Indazole 6-Chloro-1H-Indole 6-Chloro-1H-Pyrazolo[4,3-C]Pyridine 6-Chloro-1H-Pyrrolo[2,3-B]Pyridine 6-Chloro-1H-Pyrrolo[3,2-C]Pyridine 6-Chloro-2,3-Dihydrobenzofuran 6-Chloro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine 6-Chloro-3-Nitropyridin-2-Amine 6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine 6-Chlorobenzo[D]Oxazole 6-Chlorobenzo[D]Thiazole 6-Chlorochroman-4-One 6-Chlorochromane 6-Chloroindoline 6-Chloroindoline-2,3-Dione 6-Chloronicotinaldehyde 6-Chloronicotinic Acid 6-Chloropicolinic Acid 6-Chloropicolinonitrile 6-Chloropyridazin-3(2H)-One 6-Chloropyridin-2-Amine 6-Chloropyridin-2-Ol 6-Chloropyridin-3-Amine 6-Chloropyridine-3-Sulfonyl Chloride 6-Chloroquinoxaline 7-Chloro-1,2,3,4-Tetrahydroisoquinoline 7-Chloro-1H-Indazole 7-Chloro-1H-Indole 7-Chloro-1H-Pyrrolo[2,3-C]Pyridine 7-Chloro-2,3-Dihydrobenzofuran 7-Chloro-3,4-Dihydronaphthalen-1(2H)-One 7-Chlorobenzo[D]Thiazole 7-Chlorochromane 7-Chloroisoquinoline 7-Chloropyrazolo[1,5-A]Pyrimidine 8-Chlorochromane 8-Chloroimidazo[1,2-A]Pyridine 8-Chloroisoquinoline 8-Chloroquinazoline Ethyl 4,6-Dichloronicotinate Ethyl 5-Chloro-1H-Indole-2-Carboxylate Ethyl 6-Chloropicolinate Ethyl 7-Chloro-1H-Indole-2-Carboxylate Methyl 2,6-Dichlorobenzoate Methyl 2-Chloro-4-Fluorobenzoate Methyl 2-Chloro-6-Fluorobenzoate Methyl 2-Chlorobenzoate Methyl 2-Chloroisonicotinate Methyl 2-Chloronicotinate Methyl 3-Chlorobenzoate Methyl 3-Chloropicolinate Methyl 6-Chloropicolinate N-(2-Chlorophenyl)Acetamide N-(3-Chlorophenyl)Benzenesulfonamide N-(3-Chlorophenyl)Quinazolin-4-Amine N-(4-Chlorophenyl)Acetamide Phenyl Carbonochloridate Pyridine-2-Sulfonyl Chloride Pyridine-3-Sulfonyl Chloride Tert-Butyl (2-Chloropyridin-4-Yl)Carbamate

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2,2,2-Trichloro-Ethanone 2-Chloro-N-Acetamide 2-Chloro-N-Methyl-Acetamide 2-Chloro-N-Methylacetamide 2-Chloroacetyl 2-Chloroethyl 3-Chloro-1-Propanone 3-Chloro-Propanamide 3-Chloropropyl 4-Chloro-Butan-1-One 4-Chlorobutyl Benzothiazole-Chloride Benzoxazole-Chloride Bromo-Chloro-Benzene Carbonochloridate Chlorindole-Carboxylic Acid Chlorindole-Carboxylic-Acid Chloro-Benzimidazole Chloro-Benzoxazine Chloro-Carbazole Chloro-Fluoro-Benzene Chloro-Imidazopyridine Chloro-Indazole Chloro-Indazole-Carboxylate Chloro-Inden-Amine Chloro-Inden-One Chloro-Indene Chloro-Indole-Carboxylate Chloro-Iodo-Trifluoromethyl-Pyridine Chloro-Methyl Indole Chloro-Methyl-Indazole Chloro-Methyl-Pyrazole Chloro-Naphthyridin-One Chloro-Naphthyridine Chloro-Nitrobenzene Chloro-One Chloro-Phenyl-Boronic-Acid Chloro-Propylamine-Hydrochloride Chloro-Purine Chloro-Pyrazolamide Chloro-Pyrazole Chloro-Pyrazole-Carboxylate Chloro-Pyrazolopyridine Chloro-Pyrrolopyridine Chloro-Pyrrolopyrimidine Chloro-Thiadiazole Chloro-Trifluoromethyl-Pyridin-Amine Chloro-Trifluoromethyl-Pyridine Chloroacetamide Chloroacetyl Chloroaniline Chlorobenzaldehyde Chlorobenzamide Chlorobenzene Chlorobenzenesulfonamide Chlorobenzofuran Chlorobenzothiazole Chlorobenzotrifluoride Chlorobenzyl Chlorobutyl Chlorobutyl Chlorocarbonyl Chlorochroman Chloroethoxy Chloroethoxy Chloroethyl Chloroethylamino Chloroimidazo Chloroindole Chloroisobenzofuran Chloromethyl Chloromethylbutyl Chlorooxazole Chlorophenyl Chlorophthalazin Chloropicolinaldehyde Chloropicolinamide Chloropropane Chloropropane Chloropropoxy Chloropropoxy Chloropropyl Chloropyrazine Chloropyridazine Chloropyridine Chloropyrimidine Chloroquinazoline Chloroquinoline Chloroquinoxaline Chlorotoluene Dichloride Dichloro Dichloroaniline Dichloroanthracene Dichlorobenzaldehyde Dichlorobenzamide Dichlorobenzenesulfonamide Dichloroisonicotinaldehyde Dichloromethyl Dichloromethyl Dichloronicotinaldehyde Dichloronicotinate Dichloronicotinic Dichloronicotinic Dichloronicotinic Acid Dichloropalladium Dichloropalladium Dichloropyridazine Dichloropyrimidine Dichloroquinoline Nicotinoyl-Chloride Tetrachloro Tetrachloro Tetrahydroisoquinoline-Chloride Tetrahydroquinoline-Chloride Trichloride Trichloro Trichloro Trichloroacetimidate Trichloroaniline Trichlorobenzaldehyde Trichloroethyl Trichloroethyl Trichloromethyl Trichloromethyl

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