Home Chemistry Heterocyclic Building Blocks Piperazines (9H-Fluoren-9-Yl)Methyl Piperazine-1-Carboxylate
Hydrolysis: The ester functionality in the compound can undergo hydrolysis in the presence of an acid or a base to yield (9H-fluoren-9-yl)methyl piperazine-1-carboxylic acid and the corresponding alcohol.
Acylation: You can react it with acylating agents such as acyl chlorides or anhydrides to form amides. For example, treatment with acetyl chloride would yield (9H-fluoren-9-yl)methyl piperazine-1-acetate.
Reduction: The carbonyl group in the ester can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Alkylation: The piperazine nitrogen atoms are nucleophilic and can undergo alkylation reactions with alkyl halides or alkylating agents.
N-Deprotection: If you want to remove the protecting group (the fluorenyl group), you can treat it with suitable reagents and conditions, like acid-catalyzed hydrolysis or hydrogenation.
Substitution Reactions: The piperazine ring can undergo substitution reactions with various electrophiles, depending on the reaction conditions. For example, you can perform N-alkylation reactions to introduce different substituents onto the piperazine nitrogen atoms.
Cyclization: Depending on the reaction conditions, it may be possible to perform cyclization reactions to form fused or bridged ring structures.
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(R)-1-Fmoc-4-Boc-piperazine-2-carboxylicacid
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N-4-Boc-N-1-Fmoc-2-piperazine Acetic Acid
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(S)-1-N-Boc-4-N-Fmoc-piperazine2-carboxylic acid
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(S)-1-Fmoc-4-Boc-Piperazine-2-Carboxylic acid
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