Home Chemistry Organic Building Blocks Aryls Diphenylphosphine Oxide
Hydrolysis: Diphenylphosphine oxide can undergo hydrolysis in the presence of water or aqueous acids to form phosphoric acid and phenol.
Reduction: Diphenylphosphine oxide can be reduced to diphenylphosphine (C6H5)2PH, usually using strong reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: It can be oxidized to form various products, depending on the oxidizing agent used. For instance, it can be oxidized to diphenylphosphinic acid [(C6H5)2PO(OH)] or diphenylphosphine dioxide [(C6H5)2P(O)2], among other possibilities.
Wittig Reaction: Diphenylphosphine oxide can be used in a Wittig reaction, where it reacts with an aldehyde or ketone to form an alkene, commonly referred to as the Wittig olefination. In this reaction, the oxygen atom of the phosphine oxide is replaced by the formation of a carbon-carbon double bond.
Phosphorylation: Diphenylphosphine oxide can be phosphorylated to introduce a phosphoryl group (PO3H2) onto various organic substrates. This is often employed in the synthesis of organophosphorus compounds.
Grignard Reaction: It can react with Grignard reagents to form a variety of organophosphorus compounds.
Halogenation: Diphenylphosphine oxide can be halogenated, such as chlorination or bromination, depending on the conditions and reagents used.
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Bis(4-(tert-butyl)phenyl)phosphine oxide
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Bis(4-(trifluoromethyl)phenyl)phosphine oxide
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Bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine oxide
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tert-Butyl ((diphenylphosphoryl)methyl)sulfonylcarbamate
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