The Urea Transporter (UT) family is responsible for regulating the transmembrane transport of urea, primarily including two subfamilies, UT-A and UT-B. They consist of multiple transmembrane domains and are mainly located on the cell membranes of the kidneys, red blood cells, and other tissues. The UT family is involved in regulating fluid balance, the urea cycle, and osmotic pressure balance by facilitating the passive transport of urea, affecting cell permeability and metabolism. The expression of UT family members is specific in different tissues and cells, and their gene mutations or expression abnormalities are associated with various diseases, including diabetes insipidus, kidney diseases, and red blood cell abnormalities.